SCHEMBL2397439

SCHEMBL2397439

O=C(O)C(F)(F)Oc1ccc(F)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.57
PPARA Q07869 6/20 0.40
EPHX2 P34913 2/20 0.40
MEN1 O00255 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
MAPT P10636 1/20 0.40
CYP2C19 P33261 1/20 0.40
KMT2A Q03164 1/20 0.40
ALDH1A1 P00352 1/20 0.40
TSHR P16473 1/20 0.40
HSD17B10 Q99714 1/20 0.40
NR4A2 P43354 1/20 0.40
HSD11B1 P28845 1/20 0.39
PTPN1 P18031 1/20 0.39
NOTUM Q6P988 1/20 0.38
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
PPARG P37231 4/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23519124 0.94 GAA (0.53) GAAPPARAEPHX2MEN1CYP1A2
SCHEMBL23519065 0.85 EPHX2 (0.55) GAAEPHX2MAPTKMT2ANOTUM
SCHEMBL17674534 0.83 SSTR4 (0.43) GAAPPARAEPHX2MEN1CYP1A2
SCHEMBL23519004 0.82 TRPV1 (0.50) PPARAEPHX2ALDH1A1CES2CES1
SCHEMBL21612881 0.82 LDHA (0.46) GAAPPARAEPHX2MEN1CYP1A2
SCHEMBL28261832 0.82 GAA (0.56) GAAEPHX2ALDH1A1HSD11B1
SCHEMBL23519083 0.82 PPARA (0.61) GAAPPARAMEN1CYP1A2CYP3A4
SCHEMBL23519394 0.82 LMNA (0.45) GAAPPARAEPHX2MEN1CYP1A2
SCHEMBL23519000 0.82 TRPV1 (0.49) GAAPPARAEPHX2MEN1CYP1A2
SCHEMBL23519097 0.80 CES2 (0.41) GAAPPARAMEN1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250188037-A1 N-(PYRROLIDIN-3-YL OR PIPERIDIN-4-YL)ACETAMIDE DERIVATIVES TAKEDA PHARMACEUTICALS CO (JP) 2025-06-12 US disclosed
CN-119585238-A N- (pyrrolidin-3-yl or piperidin-4-yl) acetamide derivatives 武田药品工业株式会社 2025-03-07 CN disclosed
EP-4499224-A1 N-(PYRROLIDIN-3-YL OR PIPERIDIN-4-YL)ACETAMIDE DERIVATIVES Takeda Pharmaceutical Company Limited (JP) 2025-02-05 EP disclosed
WO-2023187677-A1 N-(PYRROLIDIN-3-YL OR PIPERIDIN-4-YL)ACETAMIDE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-10-05 WO disclosed
WO-2023187677-A1 N-(PYRROLIDIN-3-YL OR PIPERIDIN-4-YL)ACETAMIDE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-10-05 WO disclosed
US-11641858-B2 Agricultural chemicals REDAG CROP PROTECTION LTD. (GB) 2023-05-09 US disclosed
US-11641858-B2 Agricultural chemicals REDAG CROP PROTECTION LTD. (GB) 2023-05-09 US disclosed
US-11641858-B2 Agricultural chemicals REDAG CROP PROTECTION LTD. (GB) 2023-05-09 US disclosed
US-20220127225-A1 ONIUM SALT, CHEMICALLY AMPLIFIED RESIST COMPOSITION AND PATTERNING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2022-04-28 US disclosed
CN-109071495-B Agricultural chemicals 瑞戴格作物保护公司 2022-04-19 CN disclosed
EP-3442961-B1 AGRICULTURAL CHEMICALS REDAG CROP PROT LTD (GB) 2021-03-24 EP disclosed
US-20200323209-A1 AGRICULTURAL CHEMICALS REDAG CROP PROTECTION LTD. (GB) 2020-10-15 US disclosed
CN-109071495-A Agricultural chemicals 瑞戴格作物保护公司 2018-12-21 CN disclosed
WO-2017178819-A1 AGRICULTURAL CHEMICALS REDAG CROP PROTECTION LTD (GB) 2017-10-19 WO disclosed
US-8013186-B2 Haloalkyl containing compounds as cysteine protease inhibitors VIROBAY, INC. (US) 2011-09-06 US disclosed
US-20090023781-A1 Haloalkyl Containing Compounds as Cysteine Protease Inhibitors VIROBAY, INC. (US) 2009-01-22 US disclosed
EP-1817275-A1 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS Schering Aktiengesellschaft (DE) 2007-08-15 EP disclosed
WO-2006060494-A1 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 2006-06-08 WO disclosed
EP-1091958-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2001-04-18 EP disclosed
WO-2000001692-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2000-01-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250188037-A1 N-(PYRROLIDIN-3-YL OR PIPERIDIN-4-YL)ACETAMIDE DERIVATIVES SSTR4, SSTR3, SSTR1 GAA 719/4885PPARA 1129/4885EPHX2 4455/4885
US-20220127225-A1 ONIUM SALT, CHEMICALLY AMPLIFIED RESIST COMPOSITION AND PATTERNING PROCESS CACNA1F, SLC6A5, IDUA GAA 770/4885PPARA 3475/4885EPHX2 4074/4885
US-20200323209-A1 AGRICULTURAL CHEMICALS DDT, CYP4X1, CYP1A2 GAA 1128/4885PPARA 2041/4885EPHX2 279/4885
US-20090023781-A1 Haloalkyl Containing Compounds as Cysteine Protease Inhibitors CTSF, CTSS, CTSE GAA 70/4885PPARA 2614/4885EPHX2 731/4885
US-11641858-B2 Agricultural chemicals DDT, CYP4X1, CYP1A2 GAA 1128/4885PPARA 2041/4885EPHX2 279/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.