Sugi Predict

Sugi Predict / Compounds / SCHEMBL2398063

SCHEMBL2398063

SCHEMBL2398063

O=C(Nc1cccc2cccnc12)Oc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 2/20 0.63
▸ MEN1 O00255 5/20 0.62
▸ KMT2A Q03164 5/20 0.62
▸ MAPT P10636 4/20 0.62
▸ SMN1; SMN2 Q16637 3/20 0.62
▸ ALDH1A1 P00352 2/20 0.59
▸ HSP90AA1 P07900 1/20 0.59
▸ POLB P06746 2/20 0.57
▸ TDP1 Q9NUW8 2/20 0.57
▸ KDM4E B2RXH2 2/20 0.57
▸ RECQL P46063 1/20 0.57
▸ CASP3 P42574 1/20 0.57
▸ SENP8 Q96LD8 1/20 0.57
▸ SENP7 Q9BQF6 1/20 0.57
▸ LMNA P02545 1/20 0.56
▸ SLC40A1 Q9NP59 1/20 0.56
▸ RAB9A P51151 2/20 0.55
▸ NPC1 O15118 1/20 0.55
▸ NPSR1 Q6W5P4 1/20 0.55
▸ TRPV1 Q8NER1 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19871659 0.88 KDR (0.51) KDRMEN1KMT2AMAPTSMN1; SMN2
SCHEMBL29161864 0.82 HTT (0.72) KDRMEN1KMT2AMAPTSMN1; SMN2
SCHEMBL29161880 0.82 HDAC1 (0.71) KDRMEN1KMT2AMAPTSMN1; SMN2
SCHEMBL21121176 0.82 POLB (0.68) KDRMEN1KMT2AMAPTSMN1; SMN2
SCHEMBL5251620 0.82 HSP90AA1 (0.69) KDRMEN1KMT2AMAPTSMN1; SMN2
SCHEMBL29851236 0.80 KDR (0.71) KDRMEN1KMT2AMAPTSMN1; SMN2
SCHEMBL1695444 0.80 KDR (0.71) KDRMEN1KMT2AMAPTSMN1; SMN2
SCHEMBL8789037 0.80 HDAC1 (0.62) KDRMEN1KMT2AMAPTSMN1; SMN2
SCHEMBL896116 0.79 NPC1 (0.54) MEN1KMT2AMAPTALDH1A1TDP1
SCHEMBL896310 0.79 SMN1; SMN2 (0.57) MEN1KMT2AMAPTSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240400502-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME UNIV QUEENSLAND (AU) 2024-12-05 — — US disclosed
CN-113582889-B Sulfonylureas and related compounds and uses thereof 昆士兰大学 2024-09-20 — — CN disclosed
US-11845715-B2 — — 2023-12-19 — — US disclosed
US-11845715-B2 — — 2023-12-19 — — US disclosed
US-11845715-B2 — — 2023-12-19 — — US disclosed
US-20220112159-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME UNIV QUEENSLAND (AU) 2022-04-14 — — US disclosed
CN-113582889-A Sulfonylureas and related compounds and uses thereof 昆士兰大学 2021-11-02 — — CN disclosed
CN-113563264-A Sulfonylureas and related compounds and uses thereof 昆士兰大学 2021-10-29 — — CN disclosed
EP-3888749-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME The University of Queensland (AU) 2021-10-06 — — EP disclosed
EP-3888749-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME The University of Queensland (AU) 2021-10-06 — — EP disclosed
US-20140221322-A1 HETEROARYL SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2014-08-07 — — US disclosed
US-20140066412-A1 HETEROARYL SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2014-03-06 — — US disclosed
US-20140066412-A1 HETEROARYL SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2014-03-06 — — US disclosed
US-20140066412-A1 HETEROARYL SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2014-03-06 — — US disclosed
US-8598356-B2 Heteroaryl-substituted urea modulators of fatty acid amide hydrolase JANSSEN PHARMACEUTICA NV (BE) 2013-12-03 — — US disclosed
US-20110230490-A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2011-09-22 — — US disclosed
US-20110230490-A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2011-09-22 — — US disclosed
US-20110230490-A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2011-09-22 — — US disclosed
WO-2010068452-A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2010-06-17 — — WO disclosed
WO-2010068452-A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2010-06-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220112159-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME NLRP3, PYCARD, IAPP KDR 4376/4885MEN1 3639/4885KMT2A 4072/4885
US-11845715-B2 — NLRP3, PYCARD, NOD1 KDR 4751/4885MEN1 4202/4885KMT2A 4317/4885
US-20110230490-A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, GPR119 KDR 4647/4885MEN1 3154/4885KMT2A 564/4885
US-20140221322-A1 HETEROARYL SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, GPR119 KDR 4662/4885MEN1 3385/4885KMT2A 515/4885
US-20240400502-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME NLRP3, PYCARD, IAPP KDR 4376/4885MEN1 3639/4885KMT2A 4072/4885
US-20140066412-A1 HETEROARYL SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, GPR119 KDR 4662/4885MEN1 3385/4885KMT2A 515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.