Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10134692 | 0.85 | GPR119 (0.50) | GPR119MAP4K4 | |
| SCHEMBL10134297 | 0.82 | GPR119 (0.51) | GPR119 | |
| SCHEMBL1128462 | 0.82 | GPR119 (0.45) | GPR119MAP4K4 | |
| SCHEMBL10116314 | 0.78 | GPR119 (0.47) | GPR119 | |
| SCHEMBL10116446 | 0.78 | GPR119 (0.53) | GPR119 | |
| SCHEMBL6545410 | 0.76 | ADORA2A (0.50) | GPR119MAP4K4 | |
| SCHEMBL12596632 | 0.75 | GPR119 (0.43) | GPR119 | |
| SCHEMBL13893026 | 0.74 | GPR119 (0.65) | GPR119 | |
| SCHEMBL11881284 | 0.73 | ADORA2A (0.45) | GPR119MAP4K4 | |
| SCHEMBL27449031 | 0.73 | PTGS1 (0.49) | MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8907095-B2 | Bicyclic heterocycle derivatives and their use as modulators of the activity of GPR119 | MERCK SHARP & DOHME CORP. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8907095-B2 | Bicyclic heterocycle derivatives and their use as modulators of the activity of GPR119 | MERCK SHARP & DOHME CORP. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8907095-B2 | Bicyclic heterocycle derivatives and their use as modulators of the activity of GPR119 | MERCK SHARP & DOHME CORP. (US) | 2014-12-09 | — | — | US | disclosed |
| EP-2731944-A1 | GPR 119 MODULATORS | Pfizer Inc (US) | 2014-05-21 | — | — | EP | disclosed |
| US-8580807-B2 | Bicyclic piperidine and piperazine derivatives as GPCR modulators for the treatment of obesity, diabetes and other metabolic disorders | MERCK SHARP & DOHME CORP. (US) | 2013-11-12 | — | — | US | disclosed |
| US-8580807-B2 | Bicyclic piperidine and piperazine derivatives as GPCR modulators for the treatment of obesity, diabetes and other metabolic disorders | MERCK SHARP & DOHME CORP. (US) | 2013-11-12 | — | — | US | disclosed |
| EP-2217596-B1 | BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS MODULATORS OF THE ACTIVITY OF GPR119 | MERCK SHARP & DOHME (US) | 2013-01-30 | — | — | EP | disclosed |
| EP-2217596-B1 | BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS MODULATORS OF THE ACTIVITY OF GPR119 | MERCK SHARP & DOHME (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2013011402-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2013-01-24 | — | — | WO | disclosed |
| US-20120021976-A1 | BICYCLIC PIPERIDINE AND PIPERAZINE DERIVATIVES AS GPCR MODULATORS FOR THE TREATMENT OF OBESITY, DIABETES AND OTHER METABOLIC DISORDERS | MERCK SHARP & DOHME LLC | 2012-01-26 | — | — | US | disclosed |
| US-20110212938-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS MODULATORS OF THE ACTIVITY OF GPR119 | SCHERING CORPORATION | 2011-09-01 | — | — | US | disclosed |
| EP-2217596-A2 | BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS MODULATORS OF THE ACTIVITY OF GPR119 | Schering Corporation (US) | 2010-08-18 | — | — | EP | disclosed |
| US-20100160359-A1 | Modulators of Metabolism and the Treatment of Disorders Related Thereto | ARENA PHARMACEUTICALS, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| US-20100160359-A1 | Modulators of Metabolism and the Treatment of Disorders Related Thereto | ARENA PHARMACEUTICALS, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| US-20100160359-A1 | Modulators of Metabolism and the Treatment of Disorders Related Thereto | ARENA PHARMACEUTICALS, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| WO-2009055331-A2 | BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS MODULATORS OF THE ACTIVITY OF GPR119 | SCHERING CORPORATION (US) | 2009-04-30 | — | — | WO | disclosed |
| EP-1931654-B1 | MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2009-04-22 | — | — | EP | disclosed |
| EP-1931654-A2 | MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007035355-A2 | MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-03-29 | — | — | WO | disclosed |
| WO-2007035355-A2 | MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160359-A1 | Modulators of Metabolism and the Treatment of Disorders Related Thereto | GPR119, PC, SLC5A1 | GPR119 1/4885MAP4K4 970/4885 |
| US-20120021976-A1 | BICYCLIC PIPERIDINE AND PIPERAZINE DERIVATIVES AS GPCR MODULATORS FOR THE TREATMENT OF OBESITY, DIABETES AND OTHER METABOLIC DISORDERS | GPR119, GPR55, GPR4 | GPR119 1/4885MAP4K4 1096/4885 |
| US-20110212938-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS MODULATORS OF THE ACTIVITY OF GPR119 | GPR119, GPR88, GPR180 | GPR119 1/4885MAP4K4 3349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.