Sugi Predict

Sugi Predict / Compounds / SCHEMBL240645

SCHEMBL240645

SCHEMBL240645

Nc1ccc(S(F)(F)(F)(F)F)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.50
▸ MAPT P10636 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ PDE2A O00408 2/20 0.48
▸ KDM1A O60341 1/20 0.43
▸ ALDH1A1 P00352 6/20 0.42
▸ CYP3A4 P08684 6/20 0.42
▸ TDP1 Q9NUW8 6/20 0.42
▸ TP53 P04637 1/20 0.42
▸ ALOX15 P16050 2/20 0.38
▸ MAPK1 P28482 2/20 0.38
▸ HSD17B10 Q99714 2/20 0.38
▸ ACHE P22303 1/20 0.38
▸ CA3 P07451 1/20 0.38
▸ THRB P10828 1/20 0.38
▸ CA6 P23280 1/20 0.38
▸ CASP1 P29466 1/20 0.38
▸ HIF1A Q16665 1/20 0.38
▸ CA14 Q9ULX7 1/20 0.38
▸ TSHR P16473 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8602605 0.97 MEN1 (0.47) MEN1MAPTKMT2APDE2AKDM1A
SCHEMBL17431628 0.85 MAPT (0.64) MEN1MAPTKMT2APDE2AKDM1A
SCHEMBL17431627 0.85 MAPT (0.64) MEN1MAPTKMT2APDE2AKDM1A
SCHEMBL22541195 0.85 ALDH1A1 (0.64) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL1970199 0.83 PDE2A (0.52) PDE2AKDM1A
SCHEMBL22453193 0.82 ALDH1A1 (0.48) MEN1MAPTKMT2APDE2AKDM1A
SCHEMBL21585251 0.77 MAPT (0.44) MEN1MAPTKMT2APDE2AALDH1A1
SCHEMBL17431626 0.73 PDE2A (0.46) PDE2AKDM1AALDH1A1CYP3A4TDP1
SCHEMBL944794 0.71 PDE2A (0.44) PDE2AKDM1AACHELOXL2TAAR1
SCHEMBL320609 0.71 MEN1 (1.00) MEN1MAPTKMT2AALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 336 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119560621-A Electrolyte for inhibiting dendrite growth of solid lithium metal battery and preparation process thereof 浙江领亿新能源科技有限公司 2025-03-04 — — CN claimed
EP-1888596-B1 SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS GRUENENTHAL GMBH (DE) 2014-10-22 — — EP claimed
EP-2292625-B1 SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-12-25 — — EP claimed
EP-1891004-B1 PENTAFLUOROSULPHANYL-SUBSTITUTED COMPOUND AND ITS USE FOR PRODUCING MEDICAMENTS GRUENENTHAL GMBH (DE) 2009-12-02 — — EP claimed
US-20090036704-A1 Process for Preparing 4-Pentafluorosulfanylbenzoylguanidines SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2009-02-05 — — US claimed
US-7449594-B2 Process for preparing 4-pentafluorosulfanylbenzoylguanidines SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2008-11-11 — — US claimed
EP-1848713-A2 AMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-10-31 — — EP claimed
US-20070106094-A1 Process For Preparing 4-Pentafluorosulfanylbenzoylguanidines SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-05-10 — — US claimed
US-7126026-B2 Process for preparing 4-pentafluorosulfanylbenzoylguanidines SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2006-10-24 — — US claimed
US-20060116407-A1 Amide derivatives HOFFMANN-LA ROCHE INC. 2006-06-01 — — US claimed
WO-2006053778-A2 AMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2006-05-26 — — WO claimed
US-20050131070-A1 Process for preparing 4-pentafluorosulfanylbenzoylguanidines AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2005-06-16 — — US claimed
WO-2026098560-A2 BENZENE-CONTAINING POLYCYCLIC DERIVATIVE MODULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF 上海翰森生物医药科技有限公司 2026-05-15 — — WO disclosed
EP-4713327-A1 SPIRO DERIVATIVES AS WRN INHIBITORS Insilico Medicine IP Limited (HK) 2026-03-25 — — EP disclosed
EP-3601235-B1 BICYCLIC HETEROARYL DERIVATIVES, PREPARATION AND THERAPEUTIC USES THEREOF XWPHARMA LTD (KY) 2026-03-04 — — EP disclosed
EP-4692088-A1 COMPOUND ACTING AS WRN HELICASE INHIBITOR SHANGHAI JEYOU PHARMACEUTICAL CO., LTD. (CN) 2026-02-11 — — EP disclosed
EP-0605469-B1 N-PHENYLPYRAZOLES AS INSECTICIDES AND ACARICIDES ZENECA LTD (GB) 1998-02-11 — — EP disclosed
US-5451598-A Heterocyclic compounds and insecticidal use ZENECA LIMITED (GB) 1995-09-19 — — US disclosed
EP-0605469-A1 N-PHENYLPYRAZOLES AS INSECTICIDES AND ACARICIDES ZENECA LIMITED (GB) 1994-07-13 — — EP disclosed
WO-1993006089-A1 N-PHENYLPHRAZOLES AS INSECTICIDES AND ACARICIDES ZENECA LIMITED (GB) 1993-04-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060116407-A1 Amide derivatives GLS, SDHA, GLS2 MEN1 1411/4885MAPT 3340/4885KMT2A 3329/4885
US-20090036704-A1 Process for Preparing 4-Pentafluorosulfanylbenzoylguanidines NHERF1, SLC9A1, SLC5A1 MEN1 356/4885MAPT 4785/4885KMT2A 2440/4885
US-20050131070-A1 Process for preparing 4-pentafluorosulfanylbenzoylguanidines NHERF1, SLC9A1, SLC5A1 MEN1 356/4885MAPT 4785/4885KMT2A 2440/4885
US-20070106094-A1 Process For Preparing 4-Pentafluorosulfanylbenzoylguanidines PAH, NCEH1, PNMT MEN1 285/4885MAPT 4482/4885KMT2A 2125/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.