Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2991047 | 0.86 | PTGS2 (0.67) | PTGS2AKR1C3PTGS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14349351 | 0.78 | ENPP2 (0.48) | PTGS2AKR1C3ALDH1A1SMN1; SMN2ENPP2 | |
| SCHEMBL5923820 | 0.76 | PTGS2 (0.56) | PTGS2AKR1C3PTGS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14349350 | 0.73 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2GAATSHRKMT2A | |
| SCHEMBL1107981 | 0.73 | ALDH1A1 (0.64) | PTGS2ALDH1A1SMN1; SMN2GAATSHR | |
| SCHEMBL22693607 | 0.72 | ENPP2 (0.46) | PTGS2AKR1C3SMN1; SMN2ENPP2 | |
| SCHEMBL942878 | 0.71 | ENPP2 (0.54) | PTGS2ENPP2 | |
| SCHEMBL13026657 | 0.71 | TSHR (0.59) | PTGS2ALDH1A1SMN1; SMN2GAATSHR | |
| SCHEMBL8974266 | 0.70 | PTGS2 (0.62) | PTGS2AKR1C3PTGS1TSHR | |
| SCHEMBL212242 | 0.70 | PTGS2 (1.00) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210371375-A1 | hTERT MODULATORS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210371375-A1 | hTERT MODULATORS AND METHODS OF USE | TERT, TERF2, RB1 | PTGS2 588/4885AKR1C3 1135/4885PTGS1 991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.