Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2991047 | 0.88 | PTGS2 (0.67) | PTGS2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL25667539 | 0.85 | ENPP2 (0.54) | KMT2AMEN1GAA | |
| SCHEMBL21440977 | 0.84 | ALDH1A1 (0.47) | PTGS2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL23918534 | 0.81 | KDM1A (0.52) | PTGS2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL3245767 | 0.78 | MEN1 (0.58) | PTGS2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL2877698 | 0.76 | GSK3B (0.59) | PTGS2ALDH1A1MAPK1PTGS1 | |
| SCHEMBL24065714 | 0.76 | PTGS2 (0.54) | PTGS2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL24383402 | 0.74 | ENPP2 (0.43) | — | |
| SCHEMBL5457984 | 0.74 | ENPP2 (0.43) | SMN1; SMN2 | |
| SCHEMBL14799102 | 0.74 | ALDH1A1 (0.58) | ALDH1A1KMT2AMAPTMEN1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100374416-C | P-(sulfonyl)-aryl and heteroaryls amines | HOFFMANN LA ROCHE CO LTD (CH) | 2008-03-12 | — | — | CN | disclosed |
| US-20060173075-A1 | P-(sulfonyl) aryl and heteroarylamines-as anti-inflammatory agents | KRAUSS NANCY E | 2006-08-03 | — | — | US | disclosed |
| US-7071177-B2 | P-(sulfonyl) aryl and heteroarylamines as anti-inflammatory agents | SYNTEX (U.S.A.) LLC (US) | 2006-07-04 | — | — | US | disclosed |
| CN-1708478-A | P-(sulfonyl)-aryl and heteroaryls amines | HOFFMANN LA ROCHE (CH) | 2005-12-14 | — | — | CN | disclosed |
| EP-1278723-B1 | P-(SULFONYL)-ARYL AND -HETEROARYL AMINES | HOFFMANN LA ROCHE (CH) | 2005-08-31 | — | — | EP | disclosed |
| EP-1278723-A2 | P-(SULFONYL)-ARYL AND -HETEROARYL AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-01-29 | — | — | EP | disclosed |
| US-20020052349-A1 | p-(sulfonyl) aryl and heteroarylamines as anti-inflammatory agents | SYNTEX (U.S.A.) LLC | 2002-05-02 | — | — | US | disclosed |
| WO-2001083434-A2 | P-(SULFONYL)-ARYL AND HETEROARYLS AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173075-A1 | P-(sulfonyl) aryl and heteroarylamines-as anti-inflammatory agents | PTGES, P2RX3, P2RX7 | PTGS2 12/4885ALDH1A1 974/4885KMT2A 2332/4885 |
| US-20020052349-A1 | p-(sulfonyl) aryl and heteroarylamines as anti-inflammatory agents | PTGES, P2RX3, P2RX7 | PTGS2 14/4885ALDH1A1 804/4885KMT2A 2206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.