Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | JUN | P05412 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.64 |
| ▸ | RELA | Q04206 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24089958 | 0.85 | USP2 (0.58) | ALDH1A1LMNAL3MBTL1JUNNFKB1 | |
| SCHEMBL23064708 | 0.85 | JUN (0.49) | ALDH1A1LMNAL3MBTL1JUNNFKB1 | |
| SCHEMBL6278052 | 0.84 | MAPT (0.76) | ALDH1A1LMNAL3MBTL1JUNNFKB1 | |
| SCHEMBL24089968 | 0.84 | USP2 (0.61) | ALDH1A1LMNAL3MBTL1JUNNFKB1 | |
| Methaqualone SCHEMBL29386732 | 0.81 | ALDH1A1 (1.00) | ALDH1A1LMNAL3MBTL1PDE7AMAPT | |
| Methaqualone SCHEMBL29355239 | 0.81 | ALDH1A1 (1.00) | ALDH1A1LMNAL3MBTL1PDE7AMAPT | |
| Methaqualone SCHEMBL20471677 | 0.81 | ALDH1A1 (1.00) | ALDH1A1LMNAL3MBTL1PDE7AMAPT | |
| Methaqualone SCHEMBL43892 | 0.81 | ALDH1A1 (1.00) | ALDH1A1LMNAL3MBTL1PDE7AMAPT | |
| SCHEMBL24090149 | 0.80 | ALDH1A1 (0.67) | ALDH1A1LMNAL3MBTL1JUNNFKB1 | |
| Methaqualone SCHEMBL3500629 | 0.80 | ALDH1A1 (0.97) | ALDH1A1LMNAL3MBTL1PDE7AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352366-B2 | 2-aminoquinazolinone derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2022-06-07 | — | — | US | disclosed |
| US-20220143020-A1 | 2-AMINOQUINAZOLINONE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2022-05-12 | — | — | US | disclosed |
| US-20210380598-A1 | 2-AMINOQUINAZOLINONE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2021-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220143020-A1 | 2-AMINOQUINAZOLINONE DERIVATIVE | CNKSR1, HAX1, CRKL | ALDH1A1 645/4885LMNA 2415/4885L3MBTL1 4534/4885 |
| US-20210380598-A1 | 2-AMINOQUINAZOLINONE DERIVATIVE | CNKSR1, HAX1, SLC26A3 | ALDH1A1 739/4885LMNA 2276/4885L3MBTL1 4582/4885 |
| US-11352366-B2 | 2-aminoquinazolinone derivative | CNKSR1, HAX1, SLC26A3 | ALDH1A1 739/4885LMNA 2276/4885L3MBTL1 4582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.