Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 4/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.41 |
| ▸ | ITGAL | P20701 | 4/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830978 | 0.90 | DYRK1A (0.35) | ITGB2ICAM1ITGALDHODHKMT2A | |
| SCHEMBL2408755 | 0.87 | WDR5 (0.33) | ITGB2ICAM1ITGALDHODHKMT2A | |
| SCHEMBL2410565 | 0.85 | PLCG1 (0.36) | ITGB2ICAM1ITGALKMT2AACE | |
| SCHEMBL4998747 | 0.76 | PTGS2 (0.44) | ITGB2ICAM1ITGALKMT2ANSD2 | |
| SCHEMBL2412415 | 0.75 | PTGDR2 (0.34) | ITGB2ICAM1ITGALDHODHKMT2A | |
| SCHEMBL4998745 | 0.75 | LMNA (0.35) | ITGB2ICAM1ITGALDHODHMAPT | |
| SCHEMBL2416412 | 0.74 | DHODH (0.32) | ITGB2ICAM1ITGALDHODHKMT2A | |
| SCHEMBL2411005 | 0.73 | P2RX7 (0.35) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL2408861 | 0.73 | FPR1 (0.33) | MAPTKDM4E | |
| SCHEMBL2412156 | 0.72 | DCTPP1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364979-A1 | Pyrrole compounds | Takeda Pharmaceutical Company Limited (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |