Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59858 | 0.84 | TGM2 (0.55) | TGM2GAAKMT2AALDH1A1CYP2C9 | |
| SCHEMBL397784 | 0.82 | ALDH1A1 (0.53) | TGM2GAAKMT2AALDH1A1KDM4E | |
| SCHEMBL3250028 | 0.81 | PSIP1 (0.45) | TGM2GAAKMT2AALDH1A1KDM4E | |
| SCHEMBL5082541 | 0.80 | KMT2A (0.67) | TGM2GAAKMT2AALDH1A1KDM4E | |
| SCHEMBL17258879 | 0.80 | ALDH1A1 (0.49) | GAAKMT2ATMEM97SIGMAR1ALDH1A1 | |
| SCHEMBL8337546 | 0.80 | SETDB1 (0.50) | KMT2ATMEM97SIGMAR1ALDH1A1KDM4E | |
| SCHEMBL2449430 | 0.78 | TGM2 (0.53) | TGM2GAAKMT2AALDH1A1CYP2C9 | |
| SCHEMBL410698 | 0.78 | TSHR (0.52) | TGM2GAAKMT2AALDH1A1TSHR | |
| SCHEMBL16634646 | 0.77 | TGM2 (0.45) | TGM2GAAKMT2AALDH1A1CYP2C9 | |
| SCHEMBL3270305 | 0.77 | TGM2 (0.42) | TGM2GAAKMT2AALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252339-A1 | SUBSTITUTED PURINE-2,6-DIONE COMPOUNDS AS KRAS INHIBITORS | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2021-12-16 | — | — | WO | disclosed |