Tyrphostin 51

Tyrphostin 51

SCHEMBL241622

N#CC(C#N)=C(N)/C(C#N)=C/c1cc(O)c(O)c(O)c1

nearest known ligand 0.80

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 11/20 0.80
MEN1 O00255 7/20 0.68
KMT2A Q03164 7/20 0.68
MAPT P10636 7/20 0.68
BLM P54132 6/20 0.68
KDM4E B2RXH2 6/20 0.68
TDP1 Q9NUW8 6/20 0.68
APEX1 P27695 3/20 0.68
POLB P06746 2/20 0.68
GAA P10253 2/20 0.68
ALDH1A1 P00352 7/20 0.63
HPGD P15428 6/20 0.63
HSD17B10 Q99714 5/20 0.63
CYP3A4 P08684 4/20 0.63
TSHR P16473 4/20 0.63
PMP22 Q01453 4/20 0.63
HIF1A Q16665 4/20 0.63
CYP1A2 P05177 4/20 0.63
PKM P14618 2/20 0.63
MAPK1 P28482 2/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrphostin 51 SCHEMBL1704811 1.00 EGFR (0.80) EGFRMEN1KMT2AMAPTBLM
SCHEMBL25736026 0.91 EGFR (0.68) EGFRMEN1KMT2AMAPTBLM
SCHEMBL25737631 0.83 EGFR (1.00) EGFRMEN1KMT2AMAPTBLM
SCHEMBL17610618 0.77 ALDH1A1 (1.00) EGFRMEN1KMT2AMAPTBLM
SCHEMBL10144540 0.77 ALDH1A1 (1.00) EGFRMEN1KMT2AMAPTBLM
SCHEMBL1705596 0.77 ALDH1A1 (1.00) EGFRMEN1KMT2AMAPTBLM
SCHEMBL13928220 0.76 EGFR (0.64) EGFRMEN1KMT2AMAPTBLM
SCHEMBL25736027 0.75 EGFR (0.83) EGFRMEN1KMT2AMAPTBLM
SCHEMBL6046312 0.75 KDM4E (0.72) EGFRMEN1KMT2AMAPTBLM
SCHEMBL6046314 0.75 KDM4E (0.72) EGFRMEN1KMT2AMAPTBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 178 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026107237-A1 RAS AND EGFR INHIBITORS COMBINATION THERAPY ERASCA, INC. (US) 2026-05-21 WO claimed
EP-4577832-A1 METHOD FOR PREDICTING THE RESPONSE TO AN INHIBITOR OF EGFR KINASE ACTIVITY Indivumed GmbH (DE) 2025-07-02 EP claimed
US-11390600-B2 Crystalline forms of C21H22Cl2N4O2 BIOMED VALLEY DISCOVERIES, INC. (US) 2022-07-19 US claimed
US-20200339531-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 VERTEX PHARMACEUTICALS INCORPORATED 2020-10-29 US claimed
US-10738027-B2 Crystalline forms of C21H22Cl2N4O2 BIOMED VALLEY DISCOVERIES, INC. (US) 2020-08-11 US claimed
US-20190127348-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 BIOMED VALLEY DISCOVERIES, INC. 2019-05-02 US claimed
WO-2015095807-A1 CANCER TREATMENTS USING COMBINATIONS OF EGFR AND ERK INHIBITORS BIOMED VALLEY DISCOVERIES, INC. (US) 2015-06-25 WO claimed
WO-2026107237-A1 RAS AND EGFR INHIBITORS COMBINATION THERAPY ERASCA, INC. (US) 2026-05-21 WO disclosed
WO-2026103823-A1 COMBINATION OF RAS INHIBITOR AND EGFR INHIBITOR AND USE THEREOF 广州嘉越医药科技有限公司 2026-05-21 WO disclosed
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof PARIS SCIENCES ET LETTRES (FR) 2026-03-31 US disclosed
US-20260000714-A1 C. NOVYI FOR THE TREATMENT OF SOLID TUMORS IN NON-HUMAN ANIMALS BIOMED VALLEY DISCOVERIES INC (US) 2026-01-01 US disclosed
EP-4653054-A2 C. NOVYI FOR THE TREATMENT OF SOLID TUMORS IN HUMANS Biomed Valley Discoveries, Inc. (US) 2025-11-26 EP disclosed
US-20250340627-A1 METHODS OF SELECTING, BASED ON POLYMORPHISMS, AN INFLAMMATORY BOWEL DISEASE SUBJECT FOR TREATMENT WITH AN ANTI-TL1A ANTIBODY PROMETHEUS BIOSCIENCES INC (US) 2025-11-06 US disclosed
WO-2010054051-A1 ERBB-3 (HER3)-SELECTIVE COMBINATION THERAPY SANTARIS PHARMA A/S (DK) 2010-05-14 WO disclosed
US-20100112693-A1 Differentiation of Human Embryonic Stem Cells CENTOCOR ORTHO BIOTECH, INC. 2010-05-06 US disclosed
WO-2010051223-A1 DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO THE PANCREATIC ENDOCRINE LINEAGE CENTOCOR ORTHO BIOTECH INC. (US) 2010-05-06 WO disclosed
US-20080146584-A1 Method of treating cancers using beta-lapachone or analogs or derivatives thereof LI CHIANG 2008-06-19 US disclosed
US-20080146584-A1 Method of treating cancers using beta-lapachone or analogs or derivatives thereof LI CHIANG 2008-06-19 US disclosed
US-7361691-B2 Method of treating cancers using β-lapachone or analogs or derivatives thereof ARQULE, INC. (US) 2008-04-22 US disclosed
US-7361691-B2 Method of treating cancers using β-lapachone or analogs or derivatives thereof ARQULE, INC. (US) 2008-04-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190127348-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 EGFR 569/4885MEN1 63/4885KMT2A 2938/4885
US-20250340627-A1 METHODS OF SELECTING, BASED ON POLYMORPHISMS, AN INFLAMMATORY BOWEL DISEASE SUBJECT FOR TREATMENT WITH AN ANTI-TL1A ANTIBODY TLL1, TSG101, DNASE1L3 EGFR 4770/4885MEN1 3922/4885KMT2A 1009/4885
US-20080146584-A1 Method of treating cancers using beta-lapachone or analogs or derivatives thereof SKP2, CDC25C, CDK1 EGFR 961/4885MEN1 2685/4885KMT2A 1962/4885
US-20260000714-A1 C. NOVYI FOR THE TREATMENT OF SOLID TUMORS IN NON-HUMAN ANIMALS KIT, CPA3, MKI67 EGFR 3015/4885MEN1 2427/4885KMT2A 3355/4885
US-10738027-B2 Crystalline forms of C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 EGFR 569/4885MEN1 63/4885KMT2A 2938/4885
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof BLVRB, HBG2, Q6ZSR9 EGFR 3564/4885MEN1 3100/4885KMT2A 1218/4885
US-20200339531-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 EGFR 569/4885MEN1 63/4885KMT2A 2938/4885
US-11390600-B2 Crystalline forms of C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 EGFR 569/4885MEN1 63/4885KMT2A 2938/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.