Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23889077 | 0.78 | CFD (0.47) | L3MBTL1 | |
| SCHEMBL19127918 | 0.78 | L3MBTL1 (0.44) | L3MBTL1ALDH1A1KDM4ENPC1GAA | |
| SCHEMBL28098667 | 0.76 | L3MBTL1 (0.51) | L3MBTL1ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL20646911 | 0.75 | HTR3A (0.39) | L3MBTL1ALDH1A1ELANEPTGDR2ATM | |
| SCHEMBL19126778 | 0.71 | ADORA3 (0.50) | L3MBTL1KDM4EATM | |
| SCHEMBL12329417 | 0.69 | L3MBTL1 (0.45) | L3MBTL1ALDH1A1FEN1RET | |
| SCHEMBL10063596 | 0.69 | L3MBTL1 (0.46) | L3MBTL1ALDH1A1KDM4EFEN1RET | |
| SCHEMBL25757539 | 0.66 | ALOX15 (0.49) | L3MBTL1HTTSMN1; SMN2ELANE | |
| SCHEMBL10063592 | 0.66 | ELANE (0.47) | L3MBTL1RETELANEPTGDR2APP | |
| SCHEMBL16256005 | 0.65 | SSTR4 (0.51) | L3MBTL1KDM4EHTTFEN1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3954681-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | Bristol-Myers Squibb Company (US) | 2022-02-16 | — | — | EP | disclosed |