SCHEMBL2425458

SCHEMBL2425458

CCCCCSC[C@H](N)C(=O)O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 3/20 0.58
ARG1 P05089 1/20 0.55
ARG2 P78540 1/20 0.55
NOS1 P29475 2/20 0.53
NOS3 P29474 1/20 0.53
GMNN O75496 1/20 0.50
TP53 P04637 1/20 0.50
POLB P06746 1/20 0.50
MAPT P10636 1/20 0.50
THRB P10828 1/20 0.50
CYP2C9 P11712 1/20 0.50
BLM P54132 1/20 0.50
HSD17B10 Q99714 1/20 0.50
GRIK1 P39086 3/20 0.49
GRIK2 Q13002 2/20 0.49
SLC1A2 P43004 2/20 0.49
SLC1A1 P43005 2/20 0.49
BHMT Q93088 3/20 0.47
SLC1A3 P43003 1/20 0.46
CES2 O00748 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2425454 1.00 NOS2 (0.58) NOS2ARG1ARG2NOS1NOS3
SCHEMBL11572921 0.98 NOS2 (0.57) NOS2ARG1ARG2NOS1NOS3
SCHEMBL10073278 0.98 NOS2 (0.57) NOS2ARG1ARG2NOS1NOS3
SCHEMBL29941026 0.98 NOS2 (0.57) NOS2ARG1ARG2NOS1NOS3
SCHEMBL3082545 0.98 NOS2 (0.57) NOS2ARG1ARG2NOS1NOS3
SCHEMBL3082543 0.98 NOS2 (0.57) NOS2ARG1ARG2NOS1NOS3
SCHEMBL8612866 0.98 NOS2 (0.57) NOS2ARG1ARG2NOS1NOS3
SCHEMBL9544550 0.98 NOS2 (0.57) NOS2ARG1ARG2NOS1NOS3
SCHEMBL20553470 0.98 NOS2 (0.57) NOS2ARG1ARG2NOS1NOS3
SCHEMBL11572914 0.98 NOS2 (0.57) NOS2ARG1ARG2NOS1NOS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2186512-A1 USE OF ALLYLCYSTEINE OR ITS ANALOGS AND PHARMACEUTICAL COMPOSITION THREROF Fudan University (CN) 2010-05-19 EP claimed
US-4721705-A Skin treatment compositions Chemish Adviesbureau Drs. J.C.P. Schreuder B.V. (NL) 1988-01-26 US claimed
US-20250327074-A1 THE RARE CODON RECODING PLATFORM FOR NONCANONICAL AMINO ACIDS INCORPORATION IN MAMMALIAN CELLS SHAOXING INSTITUTE, ZHEJIANG UNIVERSITY (CN) 2025-10-23 US disclosed
EP-2937334-A1 PROPIONIC ACIDS, PROPIONIC ACID ESTERS, AND RELATED COMPOUNDS Promentis Pharmaceuticals, Inc. (US) 2015-10-28 EP disclosed
US-8815905-B2 Propionic acids, propionic acid esters, and related compounds PROMENTIS PHARMACEUTICALS, INC. (US) 2014-08-26 US disclosed
US-8623919-B2 Method of synthesizing S-allyl-cysteine analogues and their therapeutic application in treating myocardial infarction FUDAN UNIVERSITY (CN) 2014-01-07 US disclosed
EP-2545033-A2 PROPIONIC ACIDS, PROPIONIC ACID ESTERS, AND RELATED COMPOUNDS Promentis Pharmaceuticals, Inc. (US) 2013-01-16 EP disclosed
WO-2011112535-A2 PROPIONIC ACIDS, PROPIONIC ACID ESTERS, AND RELATED COMPOUNDS PROMENTIS PHARMACEUTICALS, INC. (US) 2011-09-15 WO disclosed
US-20110224156-A1 Propionic Acids, Propionic Acid Esters, and Related Compounds ALBANY MOLECULAR RESEARCH, INC. 2011-09-15 US disclosed
EP-2186512-A1 USE OF ALLYLCYSTEINE OR ITS ANALOGS AND PHARMACEUTICAL COMPOSITION THREROF Fudan University (CN) 2010-05-19 EP disclosed
US-20090036534-A1 Method Of Synthesizing S-Allyl-Cysteine Analogues And Their Therapeutic Application In Treating Myocardial Infarction FUDAN UNIVERSITY (CN) 2009-02-05 US disclosed
US-5472698-A Mixture of (N-acetyl)-L-serine, N-acetylcysteine and alpha-lipoic acid which promotes ceramide production in skin cells ELIZABETH ARDEN CO., DIVISION OF CONOPCO, INC. (US) 1995-12-05 US disclosed
US-4721705-A Skin treatment compositions Chemish Adviesbureau Drs. J.C.P. Schreuder B.V. (NL) 1988-01-26 US disclosed
US-4721705-A Skin treatment compositions Chemish Adviesbureau Drs. J.C.P. Schreuder B.V. (NL) 1988-01-26 US disclosed
US-4642355-A ANGIOTENSIN CONVERTING ENZYME INHIBITORS OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 1987-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224156-A1 Propionic Acids, Propionic Acid Esters, and Related Compounds PCCA, PC, PMP22 NOS2 4503/4885ARG1 2935/4885ARG2 1635/4885
US-20090036534-A1 Method Of Synthesizing S-Allyl-Cysteine Analogues And Their Therapeutic Application In Treating Myocardial Infarction SRM, SMS, SCLY NOS2 1892/4885ARG1 2914/4885ARG2 1482/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.