Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL23629433 | 0.95 | LMNA (0.59) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL30107666 | 0.89 | LMNA (0.59) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL2381432 | 0.89 | TSHR (0.53) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL107031 | 0.89 | — | — | |
| Maleic Acid SCHEMBL7961962 | 0.89 | TSHR (0.60) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL263297 | 0.89 | TSHR (0.60) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL263298 | 0.89 | TSHR (0.60) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL8163405 | 0.89 | TSHR (0.60) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL5799074 | 0.89 | TSHR (0.60) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL106606 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110616575-A | Reactive dye for textile and environment-friendly salt-free dyeing process thereof | 万得化工科技(上海)有限公司 | 2019-12-27 | — | — | CN | claimed |
| EP-2162522-B1 | GRANULAR ENZYMATIC DETERGENT COMPOSITIONS | UNILEVER NV (NL) | 2018-07-04 | — | — | EP | claimed |
| EP-2162522-A1 | GRANULAR ENZYMATIC DETERGENT COMPOSITIONS | UNILEVER N.V. (NL) | 2010-03-17 | — | — | EP | claimed |
| WO-2009000605-A1 | GRANULAR ENZYMATIC DETERGENT COMPOSITIONS | UNILEVER N.V. (NL) | 2008-12-31 | — | — | WO | claimed |
| EP-1558717-B1 | LAUNDRY DETERGENT COMPOSITION | UNILEVER PLC (GB) | 2008-12-24 | — | — | EP | claimed |
| US-7078373-B2 | Laundry detergent composition | UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC. (US) | 2006-07-18 | — | — | US | claimed |
| EP-1558717-A1 | LAUNDRY DETERGENT COMPOSITION | UNILEVER PLC (GB) | 2005-08-03 | — | — | EP | claimed |
| WO-2004041982-A1 | LAUNDRY DETERGENT COMPOSITION | UNILEVER PLC (GB) | 2004-05-21 | — | — | WO | claimed |
| US-20040097394-A1 | Laundry detergent composition | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2004-05-20 | — | — | US | claimed |
| US-20240237639-A1 | COMPOSITION WITH ENHANCED PLANT DISEASE CONTROL EFFECT AND RAINFASTNESS OF D-TAGATOSE | MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) | 2024-07-18 | — | — | US | disclosed |
| EP-4349169-A1 | COMPOSITION HAVING ENHANCED D-TAGATOSE PLANT-BLIGHT-CONTROLLING EFFECT AND RAIN RESISTANCE | Mitsui Chemicals Crop & Life Solutions, Inc. (JP) | 2024-04-10 | — | — | EP | disclosed |
| CN-113026027-B | Oil-removing and degreasing powder and preparation method thereof | 广东多创新材料科技有限公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-112522967-B | Dyeing and finishing processing method of colored spun fabric | 江苏金太阳纺织科技股份有限公司 | 2022-05-20 | — | — | CN | disclosed |
| CN-110140468-B | Improvement method of saline-alkali soil | 旺盛生态环境股份有限公司 | 2022-04-15 | — | — | CN | disclosed |
| WO-2008148669-A1 | MECHANICALLY SENSITIVE LAUNDRY COMPONENTS AND PACKAGING THEREFOR | UNILEVER PLC (GB) | 2008-12-11 | — | — | WO | disclosed |
| WO-2006087108-A1 | DETERGENT COMPOSITION | UNILEVER PLC (GB) | 2006-08-24 | — | — | WO | disclosed |
| US-7078373-B2 | Laundry detergent composition | UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC. (US) | 2006-07-18 | — | — | US | disclosed |
| EP-1558717-A1 | LAUNDRY DETERGENT COMPOSITION | UNILEVER PLC (GB) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041982-A1 | LAUNDRY DETERGENT COMPOSITION | UNILEVER PLC (GB) | 2004-05-21 | — | — | WO | disclosed |
| US-20040097394-A1 | Laundry detergent composition | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2004-05-20 | — | — | US | disclosed |