Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL23629433 | 0.94 | LMNA (0.59) | LMNAALOX15HSD17B10TSHRTP53 | |
| Fumaric Acid SCHEMBL2425700 | 0.89 | LMNA (0.53) | LMNAALOX15HSD17B10TSHRTP53 | |
| Acrylic Acid SCHEMBL15843882 | 0.88 | LMNA (0.67) | LMNAALOX15HSD17B10TSHRTP53 | |
| Fumaric Acid SCHEMBL8986952 | 0.85 | TSHR (0.52) | LMNAALOX15HSD17B10TSHRTP53 | |
| Fumaric Acid SCHEMBL107534 | 0.81 | — | — | |
| Fumaric Acid SCHEMBL106909 | 0.81 | — | — | |
| Fumaric Acid SCHEMBL2389920 | 0.81 | LMNA (0.39) | LMNAALOX15TSHRALDH1A1FGFR4 | |
| Acrylic Acid SCHEMBL11349872 | 0.81 | LMNA (0.67) | LMNAALOX15HSD17B10TSHRTP53 | |
| Acrylic Acid SCHEMBL29632709 | 0.81 | LMNA (0.67) | LMNAALOX15HSD17B10TSHRTP53 | |
| Fumaric Acid SCHEMBL106910 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024247831-A1 | COMPOSITE PARTICLES FOR NEGATIVE ELECTRODE MATERIAL, AND SECONDARY BATTERY | パナソニックエナジー株式会社 | 2024-12-05 | — | — | WO | disclosed |
| CN-115241603-B | Heavy metal capturing diaphragm and preparation method and application thereof | 宁德卓高新材料科技有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-115241603-B | Heavy metal capturing diaphragm and preparation method and application thereof | 宁德卓高新材料科技有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-115241603-A | Heavy metal capturing diaphragm and preparation method and application thereof | 宁德卓高新材料科技有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-115241603-A | Heavy metal capturing diaphragm and preparation method and application thereof | 宁德卓高新材料科技有限公司 | 2022-10-25 | — | — | CN | disclosed |