SCHEMBL2428291

SCHEMBL2428291

C=NC(=O)NCCNC(=O)C(=C)C

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 1/20 0.33
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL316224 0.84 TGFBR1 (0.41) TGFBR1ALDH1A1
SCHEMBL20542317 0.79 TGFBR1 (0.31) TGFBR1
SCHEMBL16480239 0.78 TGFBR1 (0.35) TGFBR1ALDH1A1
SCHEMBL16267884 0.78 TGFBR1 (0.38) TGFBR1ALDH1A1
SCHEMBL16384922 0.78 EPHX1 (0.39) TGFBR1ALDH1A1
SCHEMBL11866190 0.78 TGFBR1 (0.38) TGFBR1ALDH1A1
SCHEMBL2612361 0.78 KDM4E (0.50) TGFBR1ALDH1A1
SCHEMBL112305 0.76 TGFBR1 (0.36) TGFBR1ALDH1A1
SCHEMBL1160400 0.76
SCHEMBL632876 0.75 KDM4E (0.46) TGFBR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1988873-B1 POLYMERS CONTAINING SILICONE COPOLYOL MACROMERS AND PERSONAL CARE COMPOSITIONS CONTAINING SAME LUBRIZOL ADVANCED MAT INC (US) 2013-01-09 EP claimed
US-8021650-B2 Polymers containing silicone copolyol macromers and personal care compositions containing same LUBRIZOL ADVANCED MATERIALS, INC. (US) 2011-09-20 US claimed
EP-1988873-A2 POLYMERS CONTAINING SILICONE COPOLYOL MACROMERS AND PERSONAL CARE COMPOSITIONS CONTAINING SAME Lubrizol Advanced Materials, Inc. (US) 2008-11-12 EP claimed
WO-2007101059-A2 POLYMERS CONTAINING SILICONE COPOLYOL MACROMERS AND PERSONAL CARE COMPOSITIONS CONTAINING SAME LUBRIZOL ADVANCED MATERIALS, INC. (US) 2007-09-07 WO claimed
US-20070202069-A1 Polymers Containing Silicone Copolyol Macromers and Personal Care Compositions Containing Same LUBRIZOL ADVANCED MATERIALS, INC. 2007-08-30 US claimed
WO-2020234535-A1 DEHYDRATED COATING COMPOSITION IN SOLID FORM, METHOD OF OBTAINING SAME, AND METHOD FOR REHYDRATING SAME NOF METAL COATINGS EUROPE (FR) 2020-11-26 WO disclosed
US-20200283555-A1 ALKALI-SWELLABLE EMULSION POLYMERS LUBRIZOL ADVANCED MATERIALS, INC. 2020-09-10 US disclosed
US-20190315897-A1 RHEOLOGY MODIFIER POLYMER RHODIA OPERATIONS (FR) 2019-10-17 US disclosed
US-20190002613-A1 HYDROPHOBICALLY MODIFIED ALKALI-SWELLABLE EMULSION POLYMERS LUBRIZOL ADVANCED MATERIALS, INC. 2019-01-03 US disclosed
EP-3394126-A1 HYDROPHOBICALLY MODIFIED ALKALI-SWELLABLE EMULSION POLYMERS Lubrizol Advanced Materials, Inc. (US) 2018-10-31 EP disclosed
EP-3394124-A2 ALKALI-SWELLABLE EMULSION POLYMERS Lubrizol Advanced Materials, Inc. (US) 2018-10-31 EP disclosed
WO-2017112584-A2 ALKALI-SWELLABLE EMULSION POLYMERS LUBRIZOL ADVANCED MATERIALS, INC. (US) 2017-06-29 WO disclosed
US-7153496-B2 Hair setting compositions, polymers and methods NOVEON IP HOLDINGS CORP. (US) 2006-12-26 US disclosed
US-20060251600-A1 Hair setting compositions, polymers and methods LUBRIZOL ADVANCED MATERIALS, INC. 2006-11-09 US disclosed
EP-1467698-A1 HAIR SETTING COMPOSITIONS, POLYMERS AND METHODS Noveon IP Holdings Corp. (US) 2004-10-20 EP disclosed
EP-1465932-A1 ALKALI-SWELLABLE ASSOCIATIVE POLYMERS, METHODS AND COMPOSITIONS Noveon IP Holdings Corp. (US) 2004-10-13 EP disclosed
US-20030207988-A1 Multi-purpose polymers, methods and compositons LUBRIZOL ADVANCED MATERIALS, INC. 2003-11-06 US disclosed
US-20030202953-A1 Hair setting compositions, polymers and methods LUBRIZOL ADVANCED MATERIALS, INC. 2003-10-30 US disclosed
WO-2003061615-A1 HAIR SETTING COMPOSITIONS, POLYMERS AND METHODS NOVEON IP HOLDINGS CORP. (US) 2003-07-31 WO disclosed
WO-2003062288-A1 ALKALI-SWELLABLE ASSOCIATIVE POLYMERS, METHODS AND COMPOSITIONS NOVEON IP HOLDINGS CORP. (US) 2003-07-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190315897-A1 RHEOLOGY MODIFIER POLYMER ASS1, ACMSD, MMAB TGFBR1 2164/4885ALDH1A1 1646/4885
US-20190002613-A1 HYDROPHOBICALLY MODIFIED ALKALI-SWELLABLE EMULSION POLYMERS LIPA, PHOSPHO1, ABHD16A TGFBR1 4494/4885ALDH1A1 4150/4885
US-20030202953-A1 Hair setting compositions, polymers and methods SRM, VCL, AHCYL1 TGFBR1 4431/4885ALDH1A1 494/4885
US-20200283555-A1 ALKALI-SWELLABLE EMULSION POLYMERS LIPA, PHOSPHO1, SGMS1 TGFBR1 4162/4885ALDH1A1 4062/4885
US-20060251600-A1 Hair setting compositions, polymers and methods SRM, VCL, AHCYL1 TGFBR1 4431/4885ALDH1A1 494/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.