Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29566968 | 0.85 | HTR6 (0.41) | LTA4HFLT3ACVR1RIPK2NOD2 | |
| SCHEMBL24309746 | 0.85 | HTR6 (0.41) | LTA4HFLT3ACVR1RIPK2NOD2 | |
| SCHEMBL24309611 | 0.82 | CDK1 (0.34) | LTA4HFLT3ACVR1MAPK10MAPK8 | |
| SCHEMBL24309743 | 0.80 | LTA4H (0.41) | LTA4HFLT3ACVR1MAPK10MAPK8 | |
| SCHEMBL24309866 | 0.79 | FLT3 (0.36) | LTA4HFLT3ACVR1MAPK10MAPK8 | |
| SCHEMBL24309676 | 0.79 | FLT3 (0.38) | LTA4HFLT3ACVR1MAPK10MAPK8 | |
| SCHEMBL24310587 | 0.78 | FLT3 (0.37) | LTA4HFLT3ACVR1LCKJAK3 | |
| SCHEMBL24309698 | 0.77 | CDK4 (0.37) | LTA4HFLT3CDK2TGFBR1CDK1 | |
| SCHEMBL24309516 | 0.76 | FLT3 (0.35) | LTA4HFLT3ACVR1MAPK10MAPK8 | |
| SCHEMBL24310046 | 0.76 | LTA4H (0.34) | LTA4HACVR1LCKJAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |