Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 7/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199830 | 0.86 | PIM1 (0.50) | FEN1TGFBR1PIM1ALOX5APPIM3 | |
| SCHEMBL23218015 | 0.85 | TGFBR1 (0.59) | FEN1TGFBR1ALOX5APKCNH2KDR | |
| SCHEMBL24311916 | 0.83 | TGFBR1 (0.45) | FEN1TGFBR1PIM1ALOX5APKCNH2 | |
| SCHEMBL5198271 | 0.77 | TGFBR1 (0.70) | FEN1TGFBR1PIM1PDK2 | |
| SCHEMBL29361356 | 0.77 | TGFBR1 (0.70) | FEN1TGFBR1PIM1PDK2 | |
| SCHEMBL24312341 | 0.76 | THRB (0.57) | FEN1TGFBR1 | |
| SCHEMBL5198295 | 0.75 | TGFBR1 (0.56) | FEN1TGFBR1MAP4K4 | |
| SCHEMBL23218007 | 0.75 | TGFBR1 (0.54) | FEN1TGFBR1 | |
| SCHEMBL5199498 | 0.75 | TGFBR1 (0.56) | TGFBR1PIM1PIM3PIM2MAPK1 | |
| SCHEMBL5199408 | 0.75 | PTGS2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076905-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |