Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.47 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24312429 | 0.86 | FEN1 (0.49) | PIM1PIM3PIM2TGFBR1ALOX5AP | |
| SCHEMBL5198228 | 0.84 | TGFBR1 (0.52) | PIM1TGFBR1ALOX5APFEN1MAP4K1 | |
| SCHEMBL5197608 | 0.76 | KDM4E (0.37) | PIM1TGFBR1LRRK2 | |
| SCHEMBL5197846 | 0.76 | PIM1 (0.39) | PIM1PIM3PIM2TGFBR1ACVR1B | |
| SCHEMBL5199408 | 0.76 | PTGS2 (0.46) | — | |
| SCHEMBL373516 | 0.74 | TGFBR1 (0.59) | PIM1TGFBR1MAP4K1AXLCLK2 | |
| SCHEMBL5490810 | 0.73 | TGFBR1 (0.54) | TGFBR1LRRK2 | |
| SCHEMBL23218015 | 0.73 | TGFBR1 (0.59) | TGFBR1ALOX5APFEN1KDREPHB4 | |
| SCHEMBL5199498 | 0.72 | TGFBR1 (0.56) | PIM1PIM3PIM2TGFBR1LRRK2 | |
| SCHEMBL29361356 | 0.72 | TGFBR1 (0.70) | PIM1TGFBR1FEN1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1798229-A1 | SUBSTITUTED BIPHENYL DERIVATIVE | Sankyo Company, Limited (JP) | 2007-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | COL2A1, COL1A1, FGFR3 | PIM1 4793/4885PIM3 4397/4885PIM2 4679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.