Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24314321 | 0.87 | MAPK1 (0.35) | RAB9ANPC1POLQCA12CA9 | |
| SCHEMBL24313634 | 0.87 | RAB9A (0.34) | RAB9ANPC1MAPK1LMNAALDH1A1 | |
| SCHEMBL24313661 | 0.82 | KCNK3 (0.36) | POLQMAPK1LMNAALDH1A1HTT | |
| SCHEMBL24313756 | 0.82 | LMNA (0.33) | RAB9ANPC1MAPK1LMNAALDH1A1 | |
| SCHEMBL24313907 | 0.82 | PDE2A (0.34) | RAB9ANPC1MAPK1LMNAALDH1A1 | |
| SCHEMBL22600904 | 0.81 | NPC1 (0.36) | RAB9ANPC1CA12CA9LMNA | |
| SCHEMBL24313781 | 0.79 | ALDH1A1 (0.33) | RAB9ANPC1MAPK1LMNAALDH1A1 | |
| SCHEMBL24313796 | 0.79 | RBP4 (0.42) | RAB9ANPC1LMNAALDH1A1KDM4E | |
| SCHEMBL24313926 | 0.78 | MCL1 (0.42) | POLQALDH1A1HTTKDM4EHPGD | |
| SCHEMBL29587761 | 0.78 | MCL1 (0.42) | POLQALDH1A1HTTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |