Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6671176 | 0.92 | NPC1 (0.40) | CDK8CLK2ACVR1CLK4DYRK1B | |
| SCHEMBL5234890 | 0.87 | P2RX7 (0.39) | CDK8ACVR1P2RX7GRM5NPC1 | |
| SCHEMBL31461243 | 0.86 | ALDH1A1 (0.39) | TGFBR1P2RX7NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3747756 | 0.86 | ALDH1A1 (0.39) | TGFBR1P2RX7NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5239692 | 0.85 | TGFBR1 (0.41) | CDK8CLK2ACVR1CLK4TGFBR1 | |
| SCHEMBL5235225 | 0.85 | CYP1A2 (0.49) | TGFBR1P2RX7GRM5RAB9ASMN1; SMN2 | |
| SCHEMBL29959459 | 0.85 | CYP1A2 (0.49) | TGFBR1P2RX7GRM5RAB9ASMN1; SMN2 | |
| SCHEMBL31461239 | 0.84 | MTNR1A (0.52) | TGFBR1POLBKDM4EHSD17B10PDGFRB | |
| SCHEMBL23851296 | 0.84 | MTNR1A (0.52) | TGFBR1POLBKDM4EHSD17B10PDGFRB | |
| SCHEMBL985121 | 0.83 | GRM5 (0.43) | CDK8TGFBR1CCNCP2RX7GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220089600-A1 | TGFß INHIBITOR AND PRODRUGS | FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) (ES) | 2022-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089600-A1 | TGFß INHIBITOR AND PRODRUGS | TGFB1, TGFBR1, TGFBR2 | CDK8 1517/4885CLK2 3815/4885ACVR1 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.