Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGFR | P43088 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31461243 | 1.00 | ALDH1A1 (0.39) | ALDH1A1KDM4EGAATGFBR1AURKA | |
| SCHEMBL4490632 | 0.92 | P2RX7 (0.39) | ALDH1A1KDM4EGAAAURKAKDR | |
| SCHEMBL24322279 | 0.86 | CDK8 (0.39) | ALDH1A1KDM4EGAATGFBR1SLC22A12 | |
| SCHEMBL5235225 | 0.85 | CYP1A2 (0.49) | ALDH1A1TGFBR1P2RX7SMN1; SMN2RAB9A | |
| SCHEMBL29959459 | 0.85 | CYP1A2 (0.49) | ALDH1A1TGFBR1P2RX7SMN1; SMN2RAB9A | |
| SCHEMBL31461239 | 0.84 | MTNR1A (0.52) | ALDH1A1KDM4ETGFBR1LMNA | |
| SCHEMBL23851296 | 0.84 | MTNR1A (0.52) | ALDH1A1KDM4ETGFBR1LMNA | |
| SCHEMBL12922149 | 0.83 | P2RX7 (0.36) | TGFBR1KDRSLC22A12P2RX7SMN1; SMN2 | |
| SCHEMBL985121 | 0.83 | GRM5 (0.43) | ALDH1A1TGFBR1SLC22A12P2RX7SMN1; SMN2 | |
| SCHEMBL5239692 | 0.83 | TGFBR1 (0.41) | TGFBR1AURKAKDRAURKBSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220089600-A1 | TGFß INHIBITOR AND PRODRUGS | FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) (ES) | 2022-03-24 | — | — | US | disclosed |
| US-20220089600-A1 | TGFß INHIBITOR AND PRODRUGS | FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) (ES) | 2022-03-24 | — | — | US | disclosed |
| EP-3883556-A2 | TGF? INHIBITOR AND PRODRUGS | Fundació Institut de Recerca Biomèdica IRB (Barcelona) (ES) | 2021-09-29 | — | — | EP | disclosed |
| CN-113347965-A | TGF-beta inhibitors and prodrugs | 生物医学研究机构基金会 | 2021-09-03 | — | — | CN | disclosed |
| US-7834029-B2 | Quinolinyl-pyrrolopyrazoles | ELI LILLY AND COMPANY (US) | 2010-11-16 | — | — | US | disclosed |
| US-7834029-B2 | Quinolinyl-pyrrolopyrazoles | ELI LILLY AND COMPANY (US) | 2010-11-16 | — | — | US | disclosed |
| US-7834029-B2 | Quinolinyl-pyrrolopyrazoles | ELI LILLY AND COMPANY (US) | 2010-11-16 | — | — | US | disclosed |
| US-20080027102-A1 | QUINOLINYL-PYRROLOPYRAZOLES | BEIGHT DOUGLAS W | 2008-01-31 | — | — | US | disclosed |
| US-20080027102-A1 | QUINOLINYL-PYRROLOPYRAZOLES | BEIGHT DOUGLAS W | 2008-01-31 | — | — | US | disclosed |
| US-20080027102-A1 | QUINOLINYL-PYRROLOPYRAZOLES | BEIGHT DOUGLAS W | 2008-01-31 | — | — | US | disclosed |
| US-7265225-B2 | Quinolinyl-pyrrolopyrazoles | ELI LILLY AND COMPANY (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265225-B2 | Quinolinyl-pyrrolopyrazoles | ELI LILLY AND COMPANY (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265225-B2 | Quinolinyl-pyrrolopyrazoles | ELI LILLY AND COMPANY (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |
| EP-1565471-B1 | QUINOLINYL-PYRROLOPYRAZOLES | LILLY CO ELI (US) | 2006-10-04 | — | — | EP | disclosed |
| US-20060040983-A1 | Quinolinyl-pyrrolopyrazoles | ELI LILLY AND COMPANY (US) | 2006-02-23 | — | — | US | disclosed |
| EP-1565471-A1 | QUINOLINYL-PYRROLOPYRAZOLES | ELI LILLY AND COMPANY (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004048382-A1 | QUINOLINYL-PYRROLOPYRAZOLES | ELI LILLY AND COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089600-A1 | TGFß INHIBITOR AND PRODRUGS | TGFB1, TGFBR1, TGFBR2 | ALDH1A1 734/4885KDM4E 2040/4885GAA 689/4885 |
| US-20060040983-A1 | Quinolinyl-pyrrolopyrazoles | SDHA, NQO2, SDHB | ALDH1A1 1130/4885KDM4E 3561/4885GAA 575/4885 |
| US-20080027102-A1 | QUINOLINYL-PYRROLOPYRAZOLES | SDHA, NQO2, SDHB | ALDH1A1 1130/4885KDM4E 3561/4885GAA 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.