Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | ALB | P02768 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27902181 | 0.79 | TTR (0.38) | TTRALBMEN1KMT2AGABRA1 | |
| SCHEMBL16962481 | 0.78 | TTR (0.36) | TTRALBMEN1KMT2AGABRA1 | |
| SCHEMBL1022809 | 0.74 | ENPP2 (0.44) | — | |
| SCHEMBL2296391 | 0.71 | CYP2A6 (0.44) | — | |
| SCHEMBL504640 | 0.71 | TTR (0.52) | TTRALBMEN1KMT2A | |
| SCHEMBL200313 | 0.71 | TTR (0.52) | TTRALBMEN1KMT2A | |
| SCHEMBL16960525 | 0.70 | MEN1 (0.37) | TTRALBMEN1KMT2A | |
| SCHEMBL27795923 | 0.70 | MEN1 (0.31) | TTRALBMEN1KMT2A | |
| SCHEMBL16957809 | 0.69 | MEN1 (0.35) | TTRALBMEN1KMT2A | |
| SCHEMBL25160005 | 0.69 | TTR (0.36) | TTRALBMEN1KMT2AGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230382920-A1 | SHMT Inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY | 2023-11-30 | — | — | US | disclosed |
| US-20230382920-A1 | SHMT Inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY | 2023-11-30 | — | — | US | disclosed |
| US-20230382920-A1 | SHMT Inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY | 2023-11-30 | — | — | US | disclosed |
| WO-2022066864-A1 | SHMT INHIBITORS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2022-03-31 | — | — | WO | disclosed |
| WO-2022066864-A1 | SHMT INHIBITORS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2022-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230382920-A1 | SHMT Inhibitors | SHMT1, SHMT2, BHMT | TTR 1093/4885ALB 2108/4885MEN1 1762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.