Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.51 |
| ▸ | IDO1 | P14902 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28492133 | 0.84 | XDH (0.54) | XDHIDO1ALDH1A1KDM4EGPR35 | |
| SCHEMBL30610302 | 0.82 | XDH (0.53) | XDHIDO1ALDH1A1KDM4EGAA | |
| SCHEMBL29124005 | 0.80 | AGTR1 (0.46) | ALDH1A1MAPTCYP3A4GAAMEN1 | |
| SCHEMBL31227741 | 0.78 | IDO1 (0.66) | IDO1ALDH1A1MAPTKDM4EGAA | |
| SCHEMBL30786303 | 0.78 | ALDH1A1 (0.63) | XDHIDO1ALDH1A1GAAMEN1 | |
| SCHEMBL7019052 | 0.78 | ALDH1A1 (0.63) | XDHIDO1ALDH1A1GAAMEN1 | |
| SCHEMBL26926029 | 0.77 | GPR35 (0.43) | ALDH1A1MAPTKDM4EGAAGPR35 | |
| SCHEMBL26926165 | 0.77 | GPR35 (0.40) | XDHIDO1MAPTGPR35 | |
| SCHEMBL26926510 | 0.76 | GPR35 (0.42) | XDHIDO1MAPTCYP3A4KDM4E | |
| SCHEMBL7295418 | 0.76 | KDM4E (0.65) | IDO1ALDH1A1MAPTCYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118613484-A | Antifolate linker-drug and antibody-drug conjugates | 拜奥迪斯私人有限公司 | 2024-09-06 | — | — | CN | disclosed |
| CN-116209476-A | Antifolate linker-drug and antibody-drug conjugates | 拜奥迪斯私人有限公司 | 2023-06-02 | — | — | CN | disclosed |
| US-20230144211-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | BYONDIS B.V. (NL) | 2023-05-11 | — | — | US | disclosed |
| US-20230144211-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | BYONDIS B.V. (NL) | 2023-05-11 | — | — | US | disclosed |
| US-20220119392-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | BYONDIS B.V. (NL) | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230144211-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | DHFR, FOLR1, MTHFD2 | XDH 2158/4885IDO1 1929/4885ALDH1A1 1219/4885 |
| US-20220119392-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | DHFR, FOLR1, MTHFD2 | XDH 2158/4885IDO1 1929/4885ALDH1A1 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.