Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.61 |
| ▸ | NOS3 | P29474 | 3/20 | 0.61 |
| ▸ | NOS2 | P35228 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | OGT | O15294 | 1/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.53 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PPM1D | O15297 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 3/20 | 0.41 |
| ▸ | DDO | Q99489 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30567360 | 1.00 | NOS1 (0.61) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL17260653 | 0.85 | PDE3B (0.69) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL2149352 | 0.84 | NOS1 (0.61) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL17114093 | 0.80 | TDO2 (0.51) | PDE3BPDE3A | |
| SCHEMBL1202554 | 0.77 | F2 (0.56) | LMNAKDM4EDAO | |
| SCHEMBL6590435 | 0.77 | GABRP (0.47) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL30639060 | 0.77 | F2 (0.56) | LMNAKDM4EDAO | |
| Chlorzoxazone SCHEMBL35178 | 0.76 | NOS1 (1.00) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL240915 | 0.76 | NOS1 (0.61) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL5543509 | 0.76 | NOS1 (0.61) | NOS1NOS3NOS2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240217968-A1 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2024-07-04 | — | — | US | disclosed |
| CN-115246795-B | Isoxazoline compound containing ether structure at 4-phenyl para-position, preparation method thereof and application thereof as insecticidal and bactericidal agent | 瑞普（天津）生物药业有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-117304205-A | Benzimidazole ternary fused ring compound, pharmaceutically acceptable salt thereof and application thereof | 中国科学院广州生物医药与健康研究院 | 2023-12-29 | — | — | CN | disclosed |
| US-11584717-B2 | MIF modulators | YALE UNIVERSITY (US) | 2023-02-21 | — | — | US | disclosed |
| CN-115246795-A | Isoxazoline compound with 4-phenyl para-position containing ether structure, preparation thereof and application thereof as insecticide and bactericide | 瑞普（天津）生物药业有限公司 | 2022-10-28 | — | — | CN | disclosed |
| EP-3936192-A1 | PYRROLOPYRAZOLE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2022-01-12 | — | — | EP | disclosed |
| US-20200377457-A1 | MIF MODULATORS | UNIV YALE (US) | 2020-12-03 | — | — | US | disclosed |
| US-20200377457-A1 | MIF MODULATORS | UNIV YALE (US) | 2020-12-03 | — | — | US | disclosed |
| US-20190270706-A1 | MIF MODULATORS | UNIV YALE (US) | 2019-09-05 | — | — | US | disclosed |
| US-10226452-B2 | Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-03-12 | — | — | US | disclosed |
| EP-1359908-A1 | QUINOLINES AND NITROGENATED DERIVATIVES THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-11-12 | — | — | EP | disclosed |
| EP-1316550-A1 | 6-Acylamino-5-substituted-benzoxazol-2-one compounds and method for using them | EASTMAN KODAK COMPANY (US) | 2003-06-04 | — | — | EP | disclosed |
| US-20030100545-A1 | Benzimidazolidinone derivatives as muscarinic agents | ACADIA PHARMACEUTICALS, INC. | 2003-05-29 | — | — | US | disclosed |
| WO-2003028650-A2 | BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS | ACADIA PHARMACEUTICALS, INC. (US) | 2003-04-10 | — | — | WO | disclosed |
| US-6515176-B1 | Disclosed is a 6-acylamino-5-substituted-benzoxazol-2-one compound having the structural formula I: Also disclosed is a method for forming a cyan dye-forming coupler from the above compound. The method and intermediate with a simplified | EASTMAN KODAK COMPANY | 2003-02-04 | — | — | US | disclosed |
| WO-2002056882-A1 | QUINOLINES AND NITROGENATED DERIVAIVE THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-25 | — | — | WO | disclosed |
| EP-0385664-B1 | Antiinflammatory benzoxazolones | PFIZER (US) | 1994-01-12 | — | — | EP | disclosed |
| US-5149821-A | Process and intermediates for optically active 3-formyltetrahydropyrans | PFIZER INC (US) | 1992-09-22 | — | — | US | disclosed |
| US-5086062-A | Inhibitors of lipoxygenase and-or cyclooxygenase enzymes | PFIZER INC. (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0385664-A2 | Antiinflammatory benzoxazolones | PFIZER INC. (US) | 1990-09-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240217968-A1 | PHARMACEUTICAL COMPOUND | F11, F12, ZYX | NOS1 543/4885NOS3 1546/4885NOS2 1458/4885 |
| US-11584717-B2 | MIF modulators | MIF, HMGB2, HMGB3 | NOS1 492/4885NOS3 486/4885NOS2 283/4885 |
| US-20200377457-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | NOS1 492/4885NOS3 486/4885NOS2 283/4885 |
| US-20030100545-A1 | Benzimidazolidinone derivatives as muscarinic agents | CHRM4, CHRM5, CHRM1 | NOS1 2757/4885NOS3 2913/4885NOS2 3559/4885 |
| US-10226452-B2 | Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments | ASAH1, ASAH2, ACER2 | NOS1 3304/4885NOS3 2795/4885NOS2 3353/4885 |
| US-20190270706-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | NOS1 492/4885NOS3 486/4885NOS2 283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.