SCHEMBL2446166

SCHEMBL2446166

Oc1c(Cl)cc(OCc2ccccc2)cc1Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.58
LMNA P02545 1/20 0.58
PTGS1 P23219 1/20 0.58
SLC6A2 P23975 1/20 0.58
CYP2C19 P33261 1/20 0.58
PTGS2 P35354 1/20 0.58
SLC6A3 Q01959 1/20 0.58
HIF1A Q16665 1/20 0.58
HDAC6 Q9UBN7 1/20 0.58
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
CYP1A1 P04798 1/20 0.51
CYP19A1 P11511 1/20 0.51
ACLY P53396 1/20 0.51
ALOX5 P09917 1/20 0.50
RAB9A P51151 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
NPC1 O15118 1/20 0.49
CYP4F2 P78329 1/20 0.49
CYP4A11 Q02928 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27432581 0.89 MRGPRX4 (0.51) CYP1A2LMNAPTGS1SLC6A2CYP2C19
SCHEMBL3196407 0.85 ALOX5 (0.53) CYP1A2LMNAPTGS1SLC6A2CYP2C19
SCHEMBL31725679 0.83 APP (0.53) CYP1A2LMNAPTGS1SLC6A2CYP2C19
SCHEMBL9393694 0.82 CYP1A2 (0.44) CYP1A2LMNAPTGS1SLC6A2CYP2C19
SCHEMBL1532839 0.82 LMNA (0.59) CYP1A2LMNAPTGS1SLC6A2CYP2C19
SCHEMBL208614 0.82 MEN1 (0.51) CYP1A2LMNAPTGS1SLC6A2CYP2C19
SCHEMBL21538106 0.81 MAPT (0.52) CYP1A2LMNAPTGS1SLC6A2CYP2C19
SCHEMBL1834526 0.80 CYP1A2 (0.67) CYP1A2LMNAPTGS1SLC6A2CYP2C19
SCHEMBL2007390 0.80 CYP1A2 (0.67) CYP1A2LMNAPTGS1SLC6A2CYP2C19
SCHEMBL32675258 0.80 LMNA (0.61) CYP1A2LMNAPTGS1SLC6A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2036878-B1 PROCESS FOR PRODUCTION OF ALCOHOL COMPOUND SUMITOMO CHEMICAL CO (JP) 2012-08-22 EP claimed
US-7745669-B2 Process for production of alcohol compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-29 US claimed
US-20090259074-A1 PROCESS FOR PRODUCTION OF ALCOHOL COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-10-15 US claimed
EP-2036878-A1 PROCESS FOR PRODUCTION OF ALCOHOL COMPOUND Sumitomo Chemical Company, Limited (JP) 2009-03-18 EP claimed
EP-2036878-B1 PROCESS FOR PRODUCTION OF ALCOHOL COMPOUND SUMITOMO CHEMICAL CO (JP) 2012-08-22 EP disclosed
US-8017635-B2 Phenylalkyl substituted heteroaryl derivatives FMC CORPORATION (US) 2011-09-13 US disclosed
US-7745669-B2 Process for production of alcohol compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-29 US disclosed
US-20100152045-A1 Phenylalkyl Substituted Heteroaryl Derivatives FMC CORPORATION 2010-06-17 US disclosed
US-7713970-B2 Substituted cyclic urea derivatives FMC CORPORATION (US) 2010-05-11 US disclosed
US-7671201-B2 Phenyl substituted cyclic derivatives FMC CORPORATION (US) 2010-03-02 US disclosed
US-7671201-B2 Phenyl substituted cyclic derivatives FMC CORPORATION (US) 2010-03-02 US disclosed
US-7671201-B2 Phenyl substituted cyclic derivatives FMC CORPORATION (US) 2010-03-02 US disclosed
CN-1167104-A Fluoropropene compound, insecticide containing the same and intermediate for production thereof SUMITOMO CHEMICAL CO (JP) 1997-12-10 CN disclosed
EP-0787710-A1 Fluoropropene compound, an insecticide containing the same and an intermediate for production thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-08-06 EP disclosed
WO-1997027173-A2 DIHALOPROPENE COMPOUNDS, THEIR USE AS INSECTICIDES/ACARICIDES AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-07-31 WO disclosed
EP-0785923-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1997-07-30 EP disclosed
WO-1996033160-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-10-24 WO disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
WO-1996011909-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-04-25 WO disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100152045-A1 Phenylalkyl Substituted Heteroaryl Derivatives DDT, CRYAA, CYP19A1 CYP1A2 166/4885LMNA 3377/4885PTGS1 3932/4885
US-20090259074-A1 PROCESS FOR PRODUCTION OF ALCOHOL COMPOUND XDH, ADH5, ADH1A CYP1A2 66/4885LMNA 2895/4885PTGS1 3965/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.