Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 2/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19436464 | 0.94 | PKM (0.65) | LMNAKMT2APKMMAPTALDH1A1 | |
| SCHEMBL9725429 | 0.87 | PKM (0.65) | LMNAKMT2APKMMAPTALDH1A1 | |
| SCHEMBL29513025 | 0.83 | KMT2A (0.76) | LMNAKMT2APKMMAPTALDH1A1 | |
| SCHEMBL22118764 | 0.80 | HCAR3 (0.78) | LMNAKMT2APKMMAPTALDH1A1 | |
| SCHEMBL29513080 | 0.80 | PRSS1 (0.77) | LMNAKMT2APKMKAT2BMAPT | |
| SCHEMBL9725410 | 0.80 | ALDH1A1 (0.72) | LMNAKMT2AKAT2BMAPTALDH1A1 | |
| SCHEMBL29513074 | 0.80 | PRSS1 (0.75) | LMNAKMT2APKMKAT2BMAPT | |
| SCHEMBL112074 | 0.79 | KMT2A (0.70) | LMNAKMT2APKMMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL28720505 | 0.78 | KMT2A (0.69) | LMNAKMT2APKMKAT2BMAPT | |
| SCHEMBL5674224 | 0.78 | HCAR3 (0.76) | LMNAKMT2APKMMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440076-B1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2022-06-01 | — | — | EP | disclosed |