Methylene Chloride

Methylene Chloride

SCHEMBL244765

ClCCl.O=C(O)CC(F)C(O)(F)F

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SLC22A6 Q4U2R8 1/20 0.36
TSHR P16473 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.33
FOLH1 Q04609 1/20 0.33
ACLY P53396 2/20 0.32
GABRR1 P24046 2/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29211171 0.77 SLC22A6 (0.41) SLC22A6TSHRTDP1SMN1; SMN2FOLH1
SCHEMBL1704335 0.73 SLC22A6 (0.38) SLC22A6TSHRTDP1SMN1; SMN2FOLH1
SCHEMBL28719269 0.73 SLC22A6 (0.38) SLC22A6TSHRTDP1SMN1; SMN2FOLH1
SCHEMBL1271508 0.73 SLC22A6 (0.38) SLC22A6TSHRTDP1SMN1; SMN2FOLH1
SCHEMBL16014762 0.71
SCHEMBL25288474 0.68 SLC22A6 (0.33) SLC22A6TDP1SMN1; SMN2FOLH1
SCHEMBL7599047 0.67 CYP2D6 (0.33) SLC22A6TSHRTDP1SMN1; SMN2FOLH1
SCHEMBL7598977 0.67 THRB (0.41) SLC22A6TDP1SMN1; SMN2FOLH1ACLY
SCHEMBL30979237 0.67 THRB (0.41) SLC22A6TDP1SMN1; SMN2FOLH1
Acetic Acid SCHEMBL4276426 0.66 FFAR3 (0.44) TSHRTDP1ACLYLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118047836-A Preparation method of goserelin impurity E 中肽生化有限公司 2024-05-17 CN claimed
CN-118047836-A Preparation method of goserelin impurity E 中肽生化有限公司 2024-05-17 CN disclosed
CN-109701013-B Targeted nano drug delivery system and preparation method thereof 安徽工程大学 2021-07-13 CN disclosed
US-9598466-B2 Glycopeptide constructs and uses thereof SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2017-03-21 US disclosed
EP-2368561-B1 Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response UNIV CALIFORNIA (US) 2013-12-04 EP disclosed
US-20130295042-A1 Peptides and Peptide Mimetics to Treat Pathologies Associated With Eye Disease UAB RESEARCH FOUNDATION 2013-11-07 US disclosed
US-8568766-B2 Peptides and peptide mimetics to treat pathologies associated with eye disease THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2013-10-29 US disclosed
US-8569452-B2 Preparation of phalloidin and its derivatives AMERICAN PEPTIDE COMPANY, INC. (US) 2013-10-29 US disclosed
US-20120214968-A1 Preparation of phalloidin and its derivatives BACHEM AMERICAS, INC. 2012-08-23 US disclosed
US-20120004720-A1 G-TYPE PEPTIDES AND OTHER AGENTS TO AMELIORATE ATHEROSCLEROSIS AND OTHER PATHOLOGIES THE UNIVERSITY OF ALABAMA (US) 2012-01-05 US disclosed
US-20080293639-A1 PEPTIDES AND PEPTIDE MIMETICS TO TREAT PATHOLOGIES CHARACTERIZED BY AN INFLAMMATORY RESPONSE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-11-27 US disclosed
US-20080095821-A1 PEPTIDES AND PEPTIDE MIMETICS TO TREAT PATHOLOGIES CHARACTERIZED BY AN INFLAMMATORY RESPONSE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-04-24 US disclosed
EP-1890715-A2 PEPTIDES AND PEPTIDE MIMETICS TO TREAT PATHOLOGIES CHARACTERIZED BY AN INFLAMMATORY RESPONSE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-02-27 EP disclosed
CN-101065137-A G-type peptides and other agents to ameliorate atherosclerosis and other pathologies UNIV CALIFORNIA (US) 2007-10-31 CN disclosed
EP-1799242-A2 G-TYPE PEPTIDES AND OTHER AGENTS TO AMELIORATE ATHEROSCLEROSIS AND OTHER PATHOLOGIES The Regents of the University of California (US) 2007-06-27 EP disclosed
US-20070032430-A1 Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2007-02-08 US disclosed
WO-2006118805-A9 PEPTIDES AND PEPTIDE MIMETICS TO TREAT PATHOLOGIES CHARACTERIZED BY AN INFLAMMATORY RESPONSE UNIV CALIFORNIA (US) 2007-01-18 WO disclosed
WO-2006118805-A2 PEPTIDES AND PEPTIDE MIMETICS TO TREAT PATHOLOGIES CHARACTERIZED BY AN INFLAMMATORY RESPONSE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-11-09 WO disclosed
US-20060205669-A1 G-type peptides and other agents to ameliorate atherosclerosis and other pathologies THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2006-09-14 US disclosed
WO-2006034056-A2 G-TYPE PEPTIDES AND OTHER AGENTS TO AMELIORATE ATHEROSCLEROSIS AND OTHER PATHOLOGIES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-03-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130295042-A1 Peptides and Peptide Mimetics to Treat Pathologies Associated With Eye Disease APOB, IAPP, APOL1 SLC22A6 2247/4885TSHR 2420/4885TDP1 3233/4885
US-20080095821-A1 PEPTIDES AND PEPTIDE MIMETICS TO TREAT PATHOLOGIES CHARACTERIZED BY AN INFLAMMATORY RESPONSE APOB, APOL1, GLP1R SLC22A6 3578/4885TSHR 3318/4885TDP1 2980/4885
US-20060205669-A1 G-type peptides and other agents to ameliorate atherosclerosis and other pathologies APOB, CCL2, GLP1R SLC22A6 3881/4885TSHR 3375/4885TDP1 2259/4885
US-20070032430-A1 Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response APOB, APOL1, GLP1R SLC22A6 3578/4885TSHR 3318/4885TDP1 2980/4885
US-20120004720-A1 G-TYPE PEPTIDES AND OTHER AGENTS TO AMELIORATE ATHEROSCLEROSIS AND OTHER PATHOLOGIES APOB, CCL2, GLP1R SLC22A6 3881/4885TSHR 3375/4885TDP1 2259/4885
US-20080293639-A1 PEPTIDES AND PEPTIDE MIMETICS TO TREAT PATHOLOGIES CHARACTERIZED BY AN INFLAMMATORY RESPONSE APOB, APOL1, GLP1R SLC22A6 3578/4885TSHR 3318/4885TDP1 2980/4885
US-20120214968-A1 Preparation of phalloidin and its derivatives ACTB, ACTR3, ACTR5 SLC22A6 3222/4885TSHR 2347/4885TDP1 2566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.