Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 5/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.52 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2455358 | 1.00 | HDAC2 (0.65) | HDAC2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL27680047 | 0.88 | MAPT (0.61) | HDAC2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL28087042 | 0.88 | MAPT (0.61) | HDAC2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL3239009 | 0.87 | MAPT (0.67) | HDAC2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL20303734 | 0.87 | MAPT (0.67) | HDAC2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL649508 | 0.87 | MAPT (0.67) | HDAC2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL20303732 | 0.87 | MAPT (0.67) | HDAC2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL159753 | 0.87 | MAPT (0.67) | HDAC2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL13067862 | 0.87 | HDAC2 (0.54) | HDAC2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL28107060 | 0.86 | HDAC2 (0.54) | HDAC2HDAC1HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160257677-A1 | LARGE SUBSTITUTENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2016-09-08 | — | — | US | disclosed |
| US-9156821-B2 | Large substituent, non-phenolic opioids and methods of use thereof | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2015-10-13 | — | — | US | disclosed |
| US-20150051194-A1 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2015-02-19 | — | — | US | disclosed |
| US-8901148-B2 | Large substituent, non-phenolic opioids and methods of use thereof | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2014-12-02 | — | — | US | disclosed |
| EP-1924559-B1 | 8-CARBOXAMIDO-SUBSTITUTED-2 , 6-METHANO-3-BENZAZOCINES AND 3 - CARBOXAMIDO- SUBSTITUTED MORPHANES AS OPIOID RECEPTOR BINDING AGENTS | RENSSELAER POLYTECH INST (US) | 2014-04-16 | — | — | EP | disclosed |
| US-20130345251-A1 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2013-12-26 | — | — | US | disclosed |
| US-8541586-B2 | Large substituent, non-phenolic opioids and methods of use thereof | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2013-09-24 | — | — | US | disclosed |
| EP-2266959-B1 | 8-carboxamido-substituted-2, 6-methano-3-benzazocines and 3-carboxamido-substituted morphanes as opioid receptor binding agents | RENSSELAER POLYTECH INST (US) | 2013-05-01 | — | — | EP | disclosed |
| US-20110306603-A1 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2011-12-15 | — | — | US | disclosed |
| US-8026252-B2 | Large substituent, non-phenolic opioids and methods of use thereof | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2011-09-27 | — | — | US | disclosed |
| EP-2266959-A1 | 8-carboxamido-substituted-2, 6-methano-3-benzazocines and 3-carboxamido-substituted morphanes as opioid receptor binding agents | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-1896399-B1 | BIPHENYL AND NAPHTHYL-PHENYL HYDROXAMIC ACID DERIVATIVES | SIGMA TAU IND FARMACEUTI (IT) | 2010-11-17 | — | — | EP | disclosed |
| US-20090247562-A1 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2009-10-01 | — | — | US | disclosed |
| US-7557119-B2 | analgesics, antidiarrheal agents, anticonvulsants, antitussives, anti-addiction; 8-Substituted-2,6-methano-3-benzazocines | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2009-07-07 | — | — | US | disclosed |
| EP-1924559-A2 | 8-CARBOXAMIDO-SUBSTITUTED-2 , 6-METHANO-3-BENZAZOCINES AND 3 - CARBOXAMIDO- SUBSTITUTED MORPHANES AS OPIOID RECEPTOR BINDING AGENTS | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007014137-A2 | 8-CARBOXAMIDO-SUBSTITUTED-2 , 6-METHANO-3-BENZAZOCINES AND 3 - CARBOXAMIDO- SUBSTITUTED MORPHANES AS OPIOID RECEPTOR BINDING AGENTS | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2007-02-01 | — | — | WO | disclosed |
| US-20070021457-A1 | analgesics, antidiarrheal agents, anticonvulsants, antitussives, anti-addiction; 8-Substituted-2,6-methano-3-benzazocines | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2007-01-25 | — | — | US | disclosed |
| CN-1049224-C | Polymers as alignment layer | ROLIC AG (CH) | 2000-02-09 | — | — | CN | disclosed |
| CN-1091458-A | Polymkeric substance as oriented layer | HOFFMANN LA ROCHE (CH) | 1994-08-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247562-A1 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | OPRK1, OPRM1, OPRD1 | HDAC2 1252/4885HDAC1 1281/4885HDAC6 1862/4885 |
| US-20130345251-A1 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | OPRK1, OPRM1, OPRD1 | HDAC2 1252/4885HDAC1 1281/4885HDAC6 1862/4885 |
| US-20070021457-A1 | analgesics, antidiarrheal agents, anticonvulsants, antitussives, anti-addiction; 8-Substituted-2,6-methano-3-benzazocines | OPRM1, OPRK1, OPRL1 | HDAC2 1941/4885HDAC1 2359/4885HDAC6 2783/4885 |
| US-20150051194-A1 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | OPRK1, OPRM1, OPRD1 | HDAC2 1252/4885HDAC1 1281/4885HDAC6 1862/4885 |
| US-20160257677-A1 | LARGE SUBSTITUTENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | OPRM1, OPRK1, SIGMAR1 | HDAC2 2807/4885HDAC1 2666/4885HDAC6 2873/4885 |
| US-20110306603-A1 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | OPRK1, OPRM1, OPRD1 | HDAC2 1252/4885HDAC1 1281/4885HDAC6 1862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.