SCHEMBL2456271

SCHEMBL2456271

O=S1(=O)CCN(c2ccccc2)CC1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.63
FAAH O00519 6/20 0.56
ALDH1A1 P00352 2/20 0.51
LMNA P02545 2/20 0.50
HTR3E A5X5Y0 1/20 0.50
HTR3B O95264 1/20 0.50
ADRB1 P08588 1/20 0.50
HTR3A P46098 1/20 0.50
HTR3D Q70Z44 1/20 0.50
HTR3C Q8WXA8 1/20 0.50
SIGMAR1 Q99720 1/20 0.50
CHRNA7 P36544 2/20 0.47
CYP3A4 P08684 1/20 0.47
ALOX15 P16050 1/20 0.47
CHRNB2 P17787 1/20 0.47
NFKB1 P19838 1/20 0.47
MAPK1 P28482 1/20 0.47
CHRNA3 P32297 1/20 0.47
CHRNA4 P43681 1/20 0.47
HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19281815 0.90 FAAH (0.65) KDM4EFAAHALDH1A1LMNAMAPK1
SCHEMBL12551055 0.88 KDM4E (0.61) KDM4EFAAHALDH1A1CYP3A4MAPK1
SCHEMBL15867073 0.87 KDM4E (0.50) KDM4EFAAHALDH1A1LMNAHTR3E
SCHEMBL12551059 0.83 KDM4E (0.56) KDM4EFAAHALDH1A1LMNAALOX15
SCHEMBL12551051 0.83 LTA4H (0.60) KDM4EFAAHALDH1A1LMNAALOX15
SCHEMBL12551057 0.80 KDM4E (0.53) KDM4EFAAHALDH1A1CYP3A4MAPK1
Piperidine SCHEMBL17460237 0.79 FAAH (0.54) KDM4EFAAHALDH1A1HTR3EHTR3B
SCHEMBL12551009 0.78 CHKA (0.59) KDM4EFAAHALDH1A1CYP3A4HSD17B10
SCHEMBL4563378 0.78 KDM4E (0.59) KDM4EFAAHALDH1A1KMT2AMAPT
SCHEMBL10001302 0.78 KDM4E (0.59) KDM4EALDH1A1LMNAADRB1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220127254-A1 INDAZOLYL-ISOXAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER MERCK PATENT GMBH (DE) 2022-04-28 US claimed
US-5547727-A RADIATION TRANSPARENT SUBSTRATE WITH RECORDING AND REFLECTION LAYERS WITH DYES OF CATIONIC AZOCYANINE DYES EASTMAN KODAK COMPANY (US) 1996-08-20 US claimed
EP-0717402-A2 Optical recording elements having recording layers containing cationic azo dyes EASTMAN KODAK COMPANY (US) 1996-06-19 EP claimed
EP-4663182-A2 PROPHYLACTIC OR THERAPEUTIC AGENT FOR HYPOXIC INJURY, ISCHAEMIA-REPERFUSION INJURY AND INFLAMMATION, CELL PROTECTION AGENT FOR TRANSPLANTATION, AND BIO-PRESERVATION AGENT Scent Science International Inc. (JP) 2025-12-17 EP disclosed
CN-119345196-A Preventive or therapeutic agent for hypoxia disorder, ischemia reperfusion disorder or inflammation, cytoprotective agent for transplantation, and organism preservative 脑科学香料株式会社 2025-01-24 CN disclosed
CN-119112885-A Preventive or therapeutic agent for hypoxia disorder, ischemia reperfusion disorder or inflammation, cytoprotective agent for transplantation, and organism preservative 脑科学香料株式会社 2024-12-13 CN disclosed
CN-119015277-A Preventive or therapeutic agent for hypoxia disorder, ischemia reperfusion disorder or inflammation, cytoprotective agent for transplantation, and organism preservative 脑科学香料株式会社 2024-11-26 CN disclosed
US-20240382497-A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR HYPOXIC INJURY, ISCHAEMIA-REPERFUSION INJURY AND INFLAMMATION, CELL PROTECTION AGENT FOR TRANSPLANTATION, AND BIO-PRESERVATION AGENT SCENT SCIENCE INTERNATIONAL INC. (JP) 2024-11-21 US disclosed
US-12076325-B2 Prophylactic or therapeutic agent for hypoxic injury, ischaemia-reperfusion injury and inflammation, cell protection agent for transplantation, and bio-preservation agent SCENT SCIENCE INTERNATIONAL INC. (JP) 2024-09-03 US disclosed
CN-111918649-B Preventive or therapeutic agent for hypoxia disorder, ischemia reperfusion disorder or inflammation, cytoprotective agent for transplantation, and organism preservative 脑科学香料株式会社 2024-07-30 CN disclosed
US-20230183595-A1 WELL DEFINED LOW MOLECULAR WEIGHT DISPERSANT POLYMETHACRYLATES THE LUBRIZOL CORPORATION (US) 2023-06-15 US disclosed
EP-1478629-B1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN CO LLC (US) 2006-10-11 EP disclosed
US-20060115516-A1 Copolymerizable methine and anthraquinone compounds and articles containing them ADVANCED MEDICAL OPTICS, INC. 2006-06-01 US disclosed
US-6919329-B2 N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives PHARMACIA & UPJOHN COMPANY (US) 2005-07-19 US disclosed
EP-1478629-A1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN COMPANY (US) 2004-11-24 EP disclosed
US-20040147760-A1 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives PHARMACIA & UPJOHN COMPANY 2004-07-29 US disclosed
US-20040044052-A1 N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives PHARMACIA & UPJOHN COMPANY 2004-03-04 US disclosed
WO-2003072553-A1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN COMPANY (US) 2003-09-04 WO disclosed
US-5547727-A RADIATION TRANSPARENT SUBSTRATE WITH RECORDING AND REFLECTION LAYERS WITH DYES OF CATIONIC AZOCYANINE DYES EASTMAN KODAK COMPANY (US) 1996-08-20 US disclosed
EP-0717402-A2 Optical recording elements having recording layers containing cationic azo dyes EASTMAN KODAK COMPANY (US) 1996-06-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060115516-A1 Copolymerizable methine and anthraquinone compounds and articles containing them AAAS, IK, CYBA KDM4E 273/4885FAAH 1406/4885ALDH1A1 868/4885
US-20240382497-A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR HYPOXIC INJURY, ISCHAEMIA-REPERFUSION INJURY AND INFLAMMATION, CELL PROTECTION AGENT FOR TRANSPLANTATION, AND BIO-PRESERVATION AGENT TRPA1, TRPV1, TRPM8 KDM4E 4841/4885FAAH 1826/4885ALDH1A1 335/4885
US-12076325-B2 Prophylactic or therapeutic agent for hypoxic injury, ischaemia-reperfusion injury and inflammation, cell protection agent for transplantation, and bio-preservation agent TRPA1, TRPV1, TRPM8 KDM4E 4841/4885FAAH 1826/4885ALDH1A1 335/4885
US-20040147760-A1 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives OXA1L, AADAC, MT-ND5 KDM4E 905/4885FAAH 2436/4885ALDH1A1 956/4885
US-20040044052-A1 N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives OXA1L, AADAC, MT-ND5 KDM4E 905/4885FAAH 2436/4885ALDH1A1 956/4885
US-20220127254-A1 INDAZOLYL-ISOXAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER KIT, TNNI3K, CILK1 KDM4E 838/4885FAAH 4696/4885ALDH1A1 421/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.