SCHEMBL2456975

SCHEMBL2456975

O=c1cc(N2CCNCC2)nc2ccccn12

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKDC P78527 4/20 0.71
HTR2C P28335 6/20 0.49
IRAK4 Q9NWZ3 1/20 0.46
ITGA2B P08514 3/20 0.46
ADRB1 P08588 2/20 0.45
NCF1 P14598 1/20 0.45
KDM4E B2RXH2 2/20 0.43
HTR3E A5X5Y0 1/20 0.43
USP2 O75604 1/20 0.43
HTR3B O95264 1/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
HTR1A P08908 1/20 0.43
MAPK1 P28482 1/20 0.43
SLC6A4 P31645 1/20 0.43
HTR7 P34969 1/20 0.43
HTT P42858 1/20 0.43
HTR3A P46098 1/20 0.43
HTR6 P50406 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL16338324 0.99 PRKDC (0.69) PRKDCHTR2CIRAK4ITGA2BADRB1
SCHEMBL27145733 0.85 PRKDC (0.74) PRKDCKDM4EUSP2ALDH1A1HTT
SCHEMBL15174176 0.83 PRKDC (0.71) PRKDCALDH1A1HTR3A
SCHEMBL31060462 0.83 PRKDC (0.71) PRKDCKDM4EADORA3ADORA2AADORA2B
SCHEMBL4544196 0.83 PRKDC (1.00) PRKDCMTOR
SCHEMBL15174083 0.82 PRKDC (0.58) PRKDCKDM4EADORA3ADORA2AADORA2B
SCHEMBL15175579 0.82 PRKDC (0.58) PRKDCKDM4EADORA3ADORA2AADORA2B
SCHEMBL16338755 0.80 PRKDC (0.62) PRKDCKDM4EADORA3ADORA2AADORA2B
SCHEMBL15174332 0.80 PRKDC (0.66) PRKDCKDM4EADORA3ADORA2AADORA2B
SCHEMBL15173852 0.80 PRKDC (0.66) PRKDCKDM4EALDH1A1ADORA3ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062460-A1 METHODS FOR TREATING ACUTE CORONARY SYNDROME USING APOA-1 FUSION PROTEINS THERIPION, INC. (US) 2026-03-05 US disclosed
US-12509501-B2 Polynucleotides encoding APOA-1 fusion polypeptides THERIPION, INC. (US) 2025-12-30 US disclosed
US-20250206806-A1 POLYNUCLEOTIDES ENCODING APOA-1 FUSION POLYPEPTIDES THERIPION, INC. (US) 2025-06-26 US disclosed
US-12331102-B2 APOA-1 fusion polypeptides and related compositions THERIPION, INC. (US) 2025-06-17 US disclosed
WO-2024247267-A1 ACCESS POINT, WIRELESS TERMINAL DEVICE, AND WIRELESS COMMUNICATION METHOD 日本電信電話株式会社 2024-12-05 WO disclosed
US-20240067646-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY HOFFMANN-LA ROCHE INC. 2024-02-29 US disclosed
US-11753407-B2 Compounds for treating spinal muscular atrophy PTC THERAPEUTICS, INC. (US) 2023-09-12 US disclosed
US-20230024372-A1 POLYNUCLEOTIDES ENCODING APOA1-RNASE FUSION POLYPEPTIDES THERIPION INC (US) 2023-01-26 US disclosed
US-11472864-B2 Polynucleotides encoding APOA1-PON1 fusion polypeptides THERIPION, INC. (US) 2022-10-18 US disclosed
US-11395822-B2 Methods for treating Huntington's disease PTC THERAPEUTICS, INC. (US) 2022-07-26 US disclosed
US-20180105526-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS INC (US) 2018-04-19 US disclosed
US-9879007-B2 Compounds for treating spinal muscular atrophy PTC THERAPEUTICS, INC. (US) 2018-01-30 US disclosed
US-20170129885-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY HOFFMANN-LA ROCHE INC. 2017-05-11 US disclosed
US-9586955-B2 Compounds for treating spinal muscular atrophy PTC THERAPEUTICS, INC. (US) 2017-03-07 US disclosed
EP-3035935-A2 SCREENING METHOD F. Hoffmann-La Roche AG (CH) 2016-06-29 EP disclosed
WO-2015024876-A2 SCREENING METHOD F. HOFFMANN-LA ROCHE AG (CH) 2015-02-26 WO disclosed
US-20150005289-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY HOFFMANN-LA ROCHE INC. 2015-01-01 US disclosed
EP-2812004-A2 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC Therapeutics, Inc. (US) 2014-12-17 EP disclosed
WO-2013119916-A2 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS, INC. (US) 2013-08-15 WO disclosed
US-20110224128-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY WHALEN ANNE 2011-09-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240067646-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY SMN1; SMN2, CPT1B, GYS1 PRKDC 4355/4885HTR2C 4677/4885IRAK4 4021/4885
US-20260062460-A1 METHODS FOR TREATING ACUTE CORONARY SYNDROME USING APOA-1 FUSION PROTEINS PON1, APOB, APOL1 PRKDC 4292/4885HTR2C 4536/4885IRAK4 938/4885
US-20150005289-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY SMN1; SMN2, CPT1B, GYS1 PRKDC 4306/4885HTR2C 4604/4885IRAK4 3726/4885
US-20110224128-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY PYGM, TNNC1, MYOF PRKDC 1392/4885HTR2C 4648/4885IRAK4 2733/4885
US-20180105526-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY SMN1; SMN2, CPT1B, GYS1 PRKDC 4306/4885HTR2C 4604/4885IRAK4 3726/4885
US-12509501-B2 Polynucleotides encoding APOA-1 fusion polypeptides APOB, PON1, APOL1 PRKDC 3478/4885HTR2C 4776/4885IRAK4 930/4885
US-11395822-B2 Methods for treating Huntington's disease HTT, HYPK, RECQL PRKDC 4478/4885HTR2C 821/4885IRAK4 4514/4885
US-20170129885-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY SMN1; SMN2, CPT1B, GYS1 PRKDC 4306/4885HTR2C 4604/4885IRAK4 3726/4885
US-11753407-B2 Compounds for treating spinal muscular atrophy SMN1; SMN2, CPT1B, GYS1 PRKDC 4759/4885HTR2C 4575/4885IRAK4 3852/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.