SCHEMBL2459231

SCHEMBL2459231

C=CCP(=O)(O)OP(=O)(O)O[PH](=O)O

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LPAR2 Q9HBW0 1/20 0.31
LPAR3 Q9UBY5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1674877 0.84 LPAR2 (0.34) LPAR2LPAR3
SCHEMBL12306859 0.82 LPAR2 (0.33) LPAR2LPAR3
SCHEMBL1559671 0.77 LPAR2 (0.35) LPAR2LPAR3
SCHEMBL12306857 0.76 BTN3A1 (0.38) LPAR2LPAR3
SCHEMBL6313775 0.76 OTC (0.30)
SCHEMBL1576765 0.75
SCHEMBL2458254 0.74
SCHEMBL7633961 0.73 FDPS (0.43) LPAR2LPAR3
SCHEMBL28636538 0.72
SCHEMBL9891091 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8017596-B2 Phosphonates useful as modulators of T-γ-9-δ-2 activity INNATE PHARMA, S.A. (FR) 2011-09-13 US disclosed
US-20100254940-A1 Compositions and Methods for Regulating an Immune Response in a Subject INNATE PHARMA, S.A. (FR) 2010-10-07 US disclosed
US-20100204184-A1 Phosphonates useful as modulators of T-gamma-9-delta-2 activity LABORATOIRES MAYOLY SPINDLER (FR) 2010-08-12 US disclosed
US-20100189681-A1 Methods of Using Phosphoantigens Together with Interleukin-2 for the Treatment of Cancer INNATE PHARMA S.A. (FR) 2010-07-29 US disclosed
WO-2010049438-A2 IMPROVED METHODS OF USING PHOSPHOANTIGENS FOR THE TREATMENT OF DISEASES INNATE PHARMA (FR) 2010-05-06 WO disclosed
EP-1569656-B1 PHOSPHOANTIGENS FOR REGULATING AN IMMUNE RESPONSE INNATE PHARMA (FR) 2010-03-03 EP disclosed
EP-2150258-A2 IMPROVED METHODS OF USING PHOSPHOANTIGENS TOGETHER WITH INTERLEUKIN-2 FOR THE TREATMENT OF CANCER Innate Pharma S.A. (FR) 2010-02-10 EP disclosed
US-20100029674-A1 Methods of Using Phosphoantigen for the Treatment of Cancer INNATE PHARMA, S.A. (FR) 2010-02-04 US disclosed
US-20090304688-A1 Methods and Compositions for Increasing the Efficiency of Therapeutic Antibodies Using Gamma Delta T Cell Activators INNATE PHARMA S.A. (FR) 2009-12-10 US disclosed
EP-2083830-A1 IMPROVED METHODS OF USING PHOSPHOANTIGEN FOR THE TREATMENT OF CANCER Innate Pharma (FR) 2009-08-05 EP disclosed
US-20070134273-A1 Composition and method for the treatment of carcinoma ROMAGNE FRANCOIS 2007-06-14 US disclosed
WO-2007057440-A2 IMPROVED METHODS OF USING PHOSPHOANTIGEN FOR THE TREATMENT OF CANCER INNATE PHARMA (FR) 2007-05-24 WO disclosed
WO-2007039635-A2 PHOSPHOANTIGEN SALTS OF ORGANIC BASES AND METHODS FOR THEIR CRYSTALLIZATION INNATE PHARMA (FR) 2007-04-12 WO disclosed
EP-1720567-A2 COMPOSITION AND METHOD FOR THE TREATMENT OF CARCINOMA Innate Pharma (FR) 2006-11-15 EP disclosed
US-20060241087-A1 Phosphonates useful as modulators of t $g(g)9$g(d)2 lymphocyte activity MONTERO JEAN-LOUIS 2006-10-26 US disclosed
US-20060194755-A1 Compositions and methods for regulating an immune response in a subject INNATE PHARMA, S.A.S. (FR) 2006-08-31 US disclosed
WO-2006067635-A2 USE OF Ϝδ T LYMPHOCYTE ACTIVATORS AS VACCINE ADJUVANT INNATE PHARMA S.A. (FR) 2006-06-29 WO disclosed
WO-2005077411-A2 COMPOSITION AND METHOD FOR THE TREATMENT OF CARCINOMA INNATE PHARMA (FR) 2005-08-25 WO disclosed
EP-1453840-A1 PHOSPHONATES USEFUL AS MODULATORS OF T-GAMMA-9-DELTA-2 LYMPHOCYTE ACTIVITY Laboratoire Mayoly Spindler (FR) 2004-09-08 EP disclosed
WO-2003050128-A1 PHOSPHONATES USEFUL AS MODULATORS OF T $G(G)9$G(D)2 LYMPHOCYTE ACTIVITY LABORATOIRE MAYOLY SPINDLER (FR) 2003-06-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100254940-A1 Compositions and Methods for Regulating an Immune Response in a Subject IFNG, IL2, ICOS LPAR2 1444/4885LPAR3 1385/4885
US-20100204184-A1 Phosphonates useful as modulators of T-gamma-9-delta-2 activity CD4, PRKCD, PRKCZ LPAR2 658/4885LPAR3 1260/4885
US-20100029674-A1 Methods of Using Phosphoantigen for the Treatment of Cancer CD4, CD74, TP53 LPAR2 1894/4885LPAR3 1706/4885
US-20100189681-A1 Methods of Using Phosphoantigens Together with Interleukin-2 for the Treatment of Cancer IL2, IL2RA, CD4 LPAR2 580/4885LPAR3 1798/4885
US-20070134273-A1 Composition and method for the treatment of carcinoma IFNG, IL2, PBK LPAR2 1931/4885LPAR3 1462/4885
US-20060194755-A1 Compositions and methods for regulating an immune response in a subject IFNG, IL2, ICOS LPAR2 1736/4885LPAR3 1486/4885
US-20090304688-A1 Methods and Compositions for Increasing the Efficiency of Therapeutic Antibodies Using Gamma Delta T Cell Activators CD4, FCGR3B, IFNG LPAR2 982/4885LPAR3 830/4885
US-20060241087-A1 Phosphonates useful as modulators of t $g(g)9$g(d)2 lymphocyte activity CD4, GNG2, PLCG2 LPAR2 331/4885LPAR3 948/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.