Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH3 | Q96Q83 | 4/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2459014 | 0.94 | GPR52 (0.41) | ALKBH3GPR52 | |
| SCHEMBL12324736 | 0.89 | CCR2 (0.46) | ALKBH3DAOCCR2NR3C1 | |
| SCHEMBL12324669 | 0.83 | ALKBH3 (0.36) | ALKBH3MBOAT4KDM4EALDH1A1HPGD | |
| SCHEMBL2454543 | 0.79 | ADCY10 (0.44) | ALKBH3CCR2KDM4EALDH1A1HPGD | |
| SCHEMBL12325089 | 0.77 | MEN1 (0.32) | ALKBH3KDM4EALDH1A1HPGD | |
| SCHEMBL2456787 | 0.76 | CCR2 (0.43) | ALKBH3CCR2NR3C1KDM4EALDH1A1 | |
| SCHEMBL2461969 | 0.75 | PNP (0.39) | KDM4EALDH1A1HPGD | |
| SCHEMBL12325090 | 0.74 | BRD4 (0.43) | KDM4EALDH1A1HPGD | |
| SCHEMBL12324671 | 0.73 | PARP14 (0.42) | ALKBH3LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL12324674 | 0.71 | SMN1; SMN2 (0.48) | ALKBH3CCR2LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |