Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 14/20 | 0.41 |
| ▸ | ALKBH3 | Q96Q83 | 3/20 | 0.36 |
| ▸ | TOP2A | P11388 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2461272 | 0.94 | ALKBH3 (0.38) | GPR52ALKBH3 | |
| SCHEMBL12324736 | 0.85 | CCR2 (0.46) | ALKBH3 | |
| SCHEMBL2459341 | 0.85 | CCR2 (0.37) | GPR52ALKBH3 | |
| SCHEMBL2454543 | 0.82 | ADCY10 (0.44) | ALKBH3 | |
| SCHEMBL12324669 | 0.79 | ALKBH3 (0.36) | ALKBH3 | |
| SCHEMBL2462018 | 0.75 | PDE10A (0.40) | ALKBH3 | |
| SCHEMBL2463316 | 0.75 | THRB (0.46) | ALKBH3 | |
| SCHEMBL12325089 | 0.74 | MEN1 (0.32) | ALKBH3 | |
| SCHEMBL2456787 | 0.73 | CCR2 (0.43) | ALKBH3 | |
| SCHEMBL2461969 | 0.72 | PNP (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |