Sugi Predict

Sugi Predict / Compounds / SCHEMBL2467149

SCHEMBL2467149

SCHEMBL2467149

COC(=O)c1c2c(c3ccc(C#N)cc3c1C)OC(c1ccccc1)(c1ccccc1N1CCN(c3ccc(OC)cc3)CC1)C=C2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PKM P14618 1/20 0.36
▸ MAPT P10636 8/20 0.36
▸ MEN1 O00255 7/20 0.36
▸ KMT2A Q03164 7/20 0.36
▸ ALDH1A1 P00352 5/20 0.36
▸ HPGD P15428 3/20 0.36
▸ HSD17B10 Q99714 3/20 0.36
▸ RXFP1 Q9HBX9 3/20 0.36
▸ NPSR1 Q6W5P4 2/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ USP2 O75604 1/20 0.34
▸ ALOX15 P16050 1/20 0.34
▸ LMNA P02545 2/20 0.34
▸ TP53 P04637 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ KDM1A O60341 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ HTR1A P08908 1/20 0.33
▸ DRD2 P14416 1/20 0.33
▸ HTR7 P34969 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2466409 0.91 PKM (0.41) PKMMAPTMEN1KMT2AALDH1A1
SCHEMBL2467152 0.80 MAPT (0.38) PKMMAPTMEN1KMT2AALDH1A1
SCHEMBL2467157 0.76 MAPT (0.33) PKMMAPTMEN1KMT2AALDH1A1
SCHEMBL6172997 0.74 PLA2G2A (0.38) MEN1KMT2AALDH1A1HPGDHSD17B10
SCHEMBL8978512 0.73 ATM (0.41) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL7608091 0.71 SMN1; SMN2 (0.41) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL10102254 0.71 ATM (0.39) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL5178231 0.70 L3MBTL1 (0.38) PKMMAPTMEN1KMT2AALDH1A1
SCHEMBL6132018 0.70 L3MBTL1 (0.41) PKMMAPTMEN1KMT2AALDH1A1
SCHEMBL17929226 0.69 ATM (0.38) MAPTMEN1KMT2AALDH1A1RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2370420-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2011-10-05 — — EP claimed
WO-2010065393-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2010-06-10 — — WO claimed
US-20090309076-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2009-12-17 — — US claimed
CN-105199708-B Photochromic compounds 光学转变公司 2020-10-27 — — CN disclosed
EP-2370420-B9 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-11-13 — — EP disclosed
EP-2370420-B1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-05-22 — — EP disclosed
US-20180291009-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-20180291007-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-20180291008-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-10005763-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2018-06-26 — — US disclosed
US-10000472-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2018-06-19 — — US disclosed
US-20160332995-A1 Photochromic Comounds TRANSITIONS OPTICAL, INC. 2016-11-17 — — US disclosed
US-9405041-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2016-08-02 — — US disclosed
US-20140154514-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2014-06-05 — — US disclosed
US-8705160-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2014-04-22 — — US disclosed
US-20120200907-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2012-08-09 — — US disclosed
US-8211338-B2 Photochromic compounds TRANSITIONS OPTICAL, INC (US) 2012-07-03 — — US disclosed
EP-2370420-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2011-10-05 — — EP disclosed
WO-2010065393-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2010-06-10 — — WO disclosed
US-20090309076-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2009-12-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180291007-A1 Photochromic Compounds CCR4, CCR8, CBR3 PKM 4051/4885MAPT 3431/4885MEN1 4729/4885
US-20160332995-A1 Photochromic Comounds CCR4, CCR3, CCR8 PKM 4037/4885MAPT 3824/4885MEN1 4594/4885
US-10005763-B2 Photochromic compounds CCR4, CCR8, CBR3 PKM 4042/4885MAPT 3402/4885MEN1 4723/4885
US-20180291008-A1 Photochromic Compounds CCR4, CBR3, CCR8 PKM 4029/4885MAPT 3410/4885MEN1 4757/4885
US-20180291009-A1 Photochromic Compounds CCR4, CCR8, CBR3 PKM 4063/4885MAPT 3424/4885MEN1 4735/4885
US-10000472-B2 Photochromic compounds CCR4, CCR8, CBR3 PKM 4042/4885MAPT 3402/4885MEN1 4723/4885
US-20120200907-A1 PHOTOCHROMIC COMPOUNDS CCR4, CCR8, CBR3 PKM 4083/4885MAPT 3507/4885MEN1 4728/4885
US-20090309076-A1 PHOTOCHROMIC COMPOUNDS CCR4, CCR8, CBR3 PKM 4042/4885MAPT 3402/4885MEN1 4723/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.