Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 10/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467149 | 0.91 | PKM (0.36) | PKMMAPTKMT2AMEN1LMNA | |
| SCHEMBL8978512 | 0.82 | ATM (0.41) | MAPTKMT2AMEN1LMNATP53 | |
| SCHEMBL7608091 | 0.80 | SMN1; SMN2 (0.41) | MAPTKMT2AMEN1LMNAMAPK1 | |
| SCHEMBL10102254 | 0.79 | ATM (0.39) | MAPTKMT2AMEN1TP53L3MBTL1 | |
| SCHEMBL17929226 | 0.78 | ATM (0.38) | MAPTKMT2AMEN1LMNATP53 | |
| SCHEMBL6172997 | 0.78 | PLA2G2A (0.38) | KMT2AMEN1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL5160384 | 0.76 | MAPT (0.40) | MAPTKMT2AMEN1LMNAPOLB | |
| SCHEMBL3822262 | 0.76 | ALDH1A1 (0.40) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL8919915 | 0.75 | MEN1 (0.38) | MAPTKMT2AMEN1LMNAPOLB | |
| SCHEMBL12610521 | 0.75 | MAPT (0.34) | MAPTKMT2AMEN1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370420-B9 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2019-11-13 | — | — | EP | disclosed |
| EP-2370420-B1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2019-05-22 | — | — | EP | disclosed |
| US-20180291008-A1 | Photochromic Compounds | TRANSITIONS OPTICAL, INC. | 2018-10-11 | — | — | US | disclosed |
| US-20180291009-A1 | Photochromic Compounds | TRANSITIONS OPTICAL, INC. | 2018-10-11 | — | — | US | disclosed |
| US-20180291007-A1 | Photochromic Compounds | TRANSITIONS OPTICAL, INC. | 2018-10-11 | — | — | US | disclosed |
| US-10005763-B2 | Photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-10000472-B2 | Photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| US-20160333262-A1 | Photochromic Compounds | TRANSITIONS OPTICAL, INC. | 2016-11-17 | — | — | US | disclosed |
| US-20160332995-A1 | Photochromic Comounds | TRANSITIONS OPTICAL, INC. | 2016-11-17 | — | — | US | disclosed |
| US-9405041-B2 | Photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-20140154514-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2014-06-05 | — | — | US | disclosed |
| US-8705160-B2 | Photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-20120200907-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-8211338-B2 | Photochromic compounds | TRANSITIONS OPTICAL, INC (US) | 2012-07-03 | — | — | US | disclosed |
| EP-2370420-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010065393-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| US-20090309076-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180291007-A1 | Photochromic Compounds | CCR4, CCR8, CBR3 | PKM 4051/4885MAPT 3431/4885KMT2A 2229/4885 |
| US-20160332995-A1 | Photochromic Comounds | CCR4, CCR3, CCR8 | PKM 4037/4885MAPT 3824/4885KMT2A 3018/4885 |
| US-10005763-B2 | Photochromic compounds | CCR4, CCR8, CBR3 | PKM 4042/4885MAPT 3402/4885KMT2A 2193/4885 |
| US-20180291008-A1 | Photochromic Compounds | CCR4, CBR3, CCR8 | PKM 4029/4885MAPT 3410/4885KMT2A 2077/4885 |
| US-20160333262-A1 | Photochromic Compounds | CCR4, CCR8, CBR3 | PKM 4042/4885MAPT 3402/4885KMT2A 2193/4885 |
| US-20180291009-A1 | Photochromic Compounds | CCR4, CCR8, CBR3 | PKM 4063/4885MAPT 3424/4885KMT2A 2244/4885 |
| US-10000472-B2 | Photochromic compounds | CCR4, CCR8, CBR3 | PKM 4042/4885MAPT 3402/4885KMT2A 2193/4885 |
| US-20120200907-A1 | PHOTOCHROMIC COMPOUNDS | CCR4, CCR8, CBR3 | PKM 4083/4885MAPT 3507/4885KMT2A 2255/4885 |
| US-20090309076-A1 | PHOTOCHROMIC COMPOUNDS | CCR4, CCR8, CBR3 | PKM 4042/4885MAPT 3402/4885KMT2A 2193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.