Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | GRN | P28799 | 1/20 | 0.31 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9967739 | 0.84 | RAPGEF4 (0.41) | TACR1S1PR1P2RX3RAPGEF4PDE2A | |
| SCHEMBL10629252 | 0.78 | TACR1 (0.39) | TACR1S1PR1PDE2AIDO1TDO2 | |
| SCHEMBL437277 | 0.78 | TACR1 (0.42) | TACR1S1PR1RAPGEF4PDE2AIDO1 | |
| SCHEMBL16770635 | 0.78 | RAPGEF4 (0.37) | TACR1S1PR1RAPGEF4PDE2AGRN | |
| SCHEMBL23627166 | 0.78 | RAPGEF4 (0.37) | TACR1S1PR1RAPGEF4PDE2AGRN | |
| SCHEMBL16516214 | 0.76 | PNMT (0.41) | TACR1S1PR1IDO1TDO2 | |
| SCHEMBL24394377 | 0.75 | TACR1 (0.40) | TACR1S1PR1PDE2AIDO1TDO2 | |
| SCHEMBL19454917 | 0.73 | DPP4 (0.40) | TACR1S1PR1IDO1TDO2 | |
| SCHEMBL11574451 | 0.72 | GABRA1 (0.46) | IDO1TDO2CNR1CNR2 | |
| SCHEMBL19321650 | 0.72 | GABRA1 (0.33) | RAPGEF4PDE2AGRNSORT1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220267300-A1 | SULFONAMIDE DERIVATIVES AND USES THEREOF | NodThera Limited (GB) | 2022-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220267300-A1 | SULFONAMIDE DERIVATIVES AND USES THEREOF | IL1B, IL1A, CASP1 | TACR1 3892/4885S1PR1 291/4885KCNH2 4056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.