Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 11/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696606 | 0.83 | ALDH1A1 (0.43) | LMNASMN1; SMN2CDK2PTGS1PTGS2 | |
| SCHEMBL27836920 | 0.81 | KMT2A (0.41) | LMNASMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL24725108 | 0.78 | SMN1; SMN2 (0.41) | LMNASMN1; SMN2PTGS2 | |
| SCHEMBL18382 | 0.76 | NR1H2 (0.41) | LMNASMN1; SMN2PTGS1PTGS2NR1H2 | |
| SCHEMBL7270618 | 0.74 | SMN1; SMN2 (0.60) | LMNASMN1; SMN2 | |
| SCHEMBL28858783 | 0.73 | LMNA (0.42) | LMNASMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL32665306 | 0.73 | LMNA (0.42) | LMNASMN1; SMN2 | |
| SCHEMBL2411422 | 0.71 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2PTGS2 | |
| SCHEMBL7984890 | 0.70 | NUDT1 (0.41) | LMNASMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL1183883 | 0.69 | SDHB (0.50) | LMNASMN1; SMN2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749427-B1 | PYRIMIDINE FUNGICIDES | ZENECA LTD (GB) | 1998-07-29 | — | — | EP | disclosed |
| US-5723471-A | Pyrimidine fungicides | ZENECA LIMITED (GB) | 1998-03-03 | — | — | US | disclosed |
| EP-0749427-A1 | PYRIMIDINE FUNGICIDES | ZENECA LIMITED (GB) | 1996-12-27 | — | — | EP | disclosed |
| WO-1995024396-A1 | PYRIMIDINE FUNGICIDES | ZENECA LIMITED (GB) | 1995-09-14 | — | — | WO | disclosed |