Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Niflumic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.66 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | TTR | P02766 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | DHODH | Q02127 | 3/20 | 0.66 |
| ▸ | GMNN | O75496 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flufenamic Acid SCHEMBL21408198 | 0.90 | PTGS2 (0.69) | MEN1KMT2ATTRPTGS2LMNA | |
| Niflumic Acid SCHEMBL840856 | 0.86 | DHODH (0.70) | MEN1KMT2ATTRPTGS2LMNA | |
| Niflumic Acid SCHEMBL5472367 | 0.84 | LMNA (0.73) | MEN1KMT2ATTRPTGS2LMNA | |
| Niflumic Acid SCHEMBL24706 | 0.81 | DHODH (1.00) | MEN1KMT2ATTRPTGS2LMNA | |
| Niflumic Acid SCHEMBL29373503 | 0.81 | DHODH (1.00) | MEN1KMT2ATTRPTGS2LMNA | |
| Niflumic Acid SCHEMBL29364001 | 0.81 | DHODH (1.00) | MEN1KMT2ATTRPTGS2LMNA | |
| Niflumic Acid SCHEMBL4886924 | 0.81 | DHODH (1.00) | MEN1KMT2ATTRPTGS2LMNA | |
| Niflumic Acid SCHEMBL8925125 | 0.80 | DHODH (0.97) | MEN1KMT2ATTRPTGS2LMNA | |
| Niflumic Acid SCHEMBL10435526 | 0.80 | LMNA (0.97) | MEN1KMT2ATTRPTGS2LMNA | |
| Terofenamate SCHEMBL8585656 | 0.79 | METTL3 (0.59) | MEN1KMT2ATTRPTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370435-A1 | ANTIOXIDANT CAMPTOTHECIN DERIVATIVES AND ANTIOXIDANT ANTINEOPLASTIC NANOSPHERES THEREOF | Cedars-Sinai Medical Center (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010060098-A1 | ANTIOXIDANT CAMPTOTHECIN DERIVATIVES AND ANTIOXIDANT ANTINEOPLASTIC NANOSPHERES THEREOF | CEDARS-SINAI MEDICAL CENTER (US) | 2010-05-27 | — | — | WO | disclosed |