Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.49 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11673254 | 1.00 | KMO (0.49) | KMOACMSDEPHX2MAP4K4PDE5A | |
| SCHEMBL11844811 | 0.93 | KMO (0.48) | KMOACMSDEPHX2MAP4K4PDE5A | |
| SCHEMBL11674849 | 0.83 | KMO (0.41) | KMOACMSDEPHX2SMN1; SMN2HDAC8 | |
| SCHEMBL11674355 | 0.83 | KMO (0.41) | KMOACMSDEPHX2SMN1; SMN2HDAC8 | |
| SCHEMBL11852519 | 0.82 | KMO (0.47) | KMOACMSDEPHX2KMT2AKDM4E | |
| SCHEMBL27808150 | 0.80 | MAP4K4 (0.41) | MAP4K4PDE5AFABP4 | |
| SCHEMBL11882602 | 0.78 | EPHX2 (0.43) | KMOACMSDEPHX2KMT2AKDM4E | |
| SCHEMBL9364527 | 0.76 | ESR1 (0.49) | MAP4K4PDE5AHIF1AFABP4 | |
| SCHEMBL11187647 | 0.75 | FABP4 (0.45) | MAP4K4PDE5AFABP4 | |
| SCHEMBL18314117 | 0.75 | PTGDR2 (0.37) | MAP4K4PDE5AKMT2AKDM4EFABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256164-A1 | NK1 and NK3 antagonists | PFIZER INC | 2005-11-17 | — | — | US | claimed |
| US-20050176700-A1 | 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension,cardiovascular or renal diseases | ACTELION PHARMACEUTICALS LTD. (CH) | 2005-08-11 | — | — | US | claimed |
| JP-53121751-A | — | — | None | — | — | JP | disclosed |
| JP-58052217-A | — | — | None | — | — | JP | disclosed |
| JP-58052218-A | — | — | None | — | — | JP | disclosed |
| CN-111808011-B | High penetration composition and its application | 泰飞尔生物医药(苏州)有限公司 | 2024-02-27 | — | — | CN | disclosed |
| US-20230233516-A1 | HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS | TECHFIELDS PHARMA CO., LTD (CN) | 2023-07-27 | — | — | US | disclosed |
| US-11541029-B2 | High penetration compositions and their applications | TECHFIELDS PHARMA CO., LTD. (CN) | 2023-01-03 | — | — | US | disclosed |
| CN-113636965-A | High penetration composition and application thereof | 于崇曦 | 2021-11-12 | — | — | CN | disclosed |
| CN-107320732-B | High penetration composition and application thereof | 于崇曦 | 2021-09-07 | — | — | CN | disclosed |
| CN-108191846-B | High penetration composition and application thereof | 于崇曦 | 2021-08-20 | — | — | CN | disclosed |
| JP-S5852217-A | ANALGESIC, ANTIPYRETIC AND ANTI-INFLAMMATORY AGENT | TAKEDA CHEM IND LTD | 1983-03-28 | — | — | JP | disclosed |
| JP-S53121751-A | PREPARATION OF INDANECARBOXYLIC ACID DERIVATIVES | TAKEDA CHEM IND LTD | 1978-10-24 | — | — | JP | disclosed |
| US-4046915-A | TREATING HEMORRHAGE | THE UPJOHN COMPANY (US) | 1977-09-06 | — | — | US | disclosed |
| US-4004026-A | Dicarboxylic acids and derivatives in the treatment of pain and inflammation | CIBA-GEIGY CORPORATION (US) | 1977-01-18 | — | — | US | disclosed |
| US-3996103-A | DERIVATIVES OF PHENYL-1-INDANCARBOXYLIC ACIDS | THE UPJOHN COMPANY (US) | 1976-12-07 | — | — | US | disclosed |
| US-3940434-A | ANTIINFLAMMATORY, ANALGESIC | CIBA-GEIGY CORPORATION (US) | 1976-02-24 | — | — | US | disclosed |
| US-3923866-A | Process for producing indan derivatives | TAKEDA CHEMICAL INDUSTRIES LTD | 1975-12-02 | — | — | US | disclosed |
| JP-S05852217-A | — | — | 0001-01-01 | — | — | JP | disclosed |
| JP-S05852218-A | — | — | 0001-01-01 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256164-A1 | NK1 and NK3 antagonists | TAC3, TACR1, TACR2 | KMO 184/4885ACMSD 3109/4885EPHX2 3159/4885 |
| US-20050176700-A1 | 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension,cardiovascular or renal diseases | REN, AGTR1, ACE | KMO 521/4885ACMSD 775/4885EPHX2 439/4885 |
| US-11541029-B2 | High penetration compositions and their applications | SLC19A1, HIRA, SLC43A1 | KMO 1055/4885ACMSD 2725/4885EPHX2 421/4885 |
| US-20230233516-A1 | HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS | SLC5A7, SLC19A1, SLC43A1 | KMO 378/4885ACMSD 3179/4885EPHX2 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.