Sugi Predict

Sugi Predict / Compounds / SCHEMBL247809

SCHEMBL247809

SCHEMBL247809

CC(C)(C)N(C(=O)O)c1ccccc1N

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.38
▸ KMT2A Q03164 4/20 0.37
▸ MAPT P10636 3/20 0.37
▸ GAA P10253 2/20 0.36
▸ MAPK13 O15264 1/20 0.36
▸ MAPK12 P53778 1/20 0.36
▸ MAPK11 Q15759 1/20 0.36
▸ MAPK14 Q16539 1/20 0.36
▸ MEN1 O00255 3/20 0.36
▸ HTT P42858 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ ALDH1A1 P00352 3/20 0.35
▸ HSD17B10 Q99714 2/20 0.35
▸ CFTR P13569 1/20 0.35
▸ POLB P06746 1/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ RIPK1 Q13546 2/20 0.33
▸ HDAC1 Q13547 2/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2C9 P11712 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3672016 0.84 MMP2 (0.44) KDM4EKMT2AMAPTGAAMEN1
SCHEMBL12497132 0.82 KDM4E (0.36) KDM4EKMT2AMAPTGAAMAPK13
SCHEMBL650663 0.80 MAPT (0.45) KDM4EKMT2AMAPTGAAMEN1
SCHEMBL6005339 0.79 TRPM8 (0.46) KMT2AMEN1HTTL3MBTL1ALDH1A1
SCHEMBL9206795 0.78 CES2 (0.36) KDM4EMAPK13MAPK12MAPK11MAPK14
SCHEMBL28449626 0.78 L3MBTL1 (0.42) KMT2AMEN1HTTL3MBTL1ALDH1A1
SCHEMBL17102731 0.77 SMN1; SMN2 (0.39) KDM4EKMT2AMAPTGAAMEN1
SCHEMBL20564934 0.77 KMT2A (0.36) KDM4EKMT2AMAPTMEN1HTT
SCHEMBL3342286 0.76 KMT2A (0.35) KMT2AMAPTGAAMEN1HTT
SCHEMBL16968516 0.76 TACR1 (0.47) KDM4EKMT2AMEN1ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023284651-A1 N-(2-AMINOPHENYL)BENZAMIDE COMPOUND AND APPLICATION THEREOF 南京明德新药研发有限公司 2023-01-19 — — WO disclosed
US-10981933-B2 Histone deacetylase inhibitors BIOMARIN PHARMACEUTICAL INC. (US) 2021-04-20 — — US disclosed
EP-3695836-A1 HISTONE DEACETYLASE INHIBITORS BioMarin Pharmaceutical Inc. (US) 2020-08-19 — — EP disclosed
US-20200148704-A1 HISTONE DEACETYLASE INHIBITORS BIOMARIN PHARMACEUTICAL INC. 2020-05-14 — — US disclosed
EP-2968251-B1 HISTONE DEACETYLASE INHIBITORS BIOMARIN PHARM INC (US) 2020-02-12 — — EP disclosed
EP-3524324-A1 HISTONE DEACETYLASE INHIBITORS BioMarin Pharmaceutical Inc. (US) 2019-08-14 — — EP disclosed
US-20190233439-A1 HISTONE DEACETYLASE INHIBITORS REPLIGEN CORPORATION 2019-08-01 — — US disclosed
US-10301323-B2 Histone deacetylase inhibitors BIOMARIN PHARMACEUTICAL INC. (US) 2019-05-28 — — US disclosed
US-10280182-B2 Histone deacetylase inhibitors BIOMARIN PHARMACEUTICAL INC. (US) 2019-05-07 — — US disclosed
EP-2680694-B1 HISTONE DEACETYLASE INHIBITORS BIOMARIN PHARM INC (US) 2019-01-02 — — EP disclosed
US-20100144732-A1 PYRIMIDINE KINASE INHIBITORS GENENTECH, INC. 2010-06-10 — — US disclosed
EP-2099771-A1 PYRIMIDINE KINASE INHIBITORS Genentech, Inc. (US) 2009-09-16 — — EP disclosed
EP-1954698-B1 SPIROCYCLIC COMPOUNDS AS HDAC INHIBITORS MERCK & CO INC (US) 2009-06-24 — — EP disclosed
EP-1951656-A1 HISTONE DEACETYLASE INHIBITORS AS THERAPEUTICS FOR NEUROLOGICAL DISEASES The Scripps Research Institute (US) 2008-08-06 — — EP disclosed
WO-2008079719-A1 PYRIMIDINE KINASE INHIBITORS GENENTECH, INC. (US) 2008-07-03 — — WO disclosed
US-20070219244-A1 Histone deacetylase inhibitors as therapeutics for neurological diseases THE SCRIPPS RESEARCH INSTITUTE (US) 2007-09-20 — — US disclosed
WO-2007058927-A1 HISTONE DEACETYLASE INHIBITORS AS THERAPEUTICS FOR NEUROLOGICAL DISEASES THE SCRIPPS RESEARCH INSTITUTE (US) 2007-05-24 — — WO disclosed
EP-0804525-A4 DIMERCAPTOTHIADIAZOLE-MERCAPTAN COUPLED COMPOUNDS AS MULTIFUNCTIONAL ADDITIVES FOR LUBRICANTS AND FUELS MOBIL OIL CORP (US) 1998-09-02 — — EP disclosed
EP-0804525-A1 DIMERCAPTOTHIADIAZOLE-MERCAPTAN COUPLED COMPOUNDS AS MULTIFUNCTIONAL ADDITIVES FOR LUBRICANTS AND FUELS MOBIL OIL CORPORATION (US) 1997-11-05 — — EP disclosed
WO-1996006903-A1 DIMERCAPTOTHIADIAZOLE-MERCAPTAN COUPLED COMPOUNDS AS MULTIFUNCTIONAL ADDITIVES FOR LUBRICANTS AND FUELS MOBIL OIL CORPORATION (US) 1996-03-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190233439-A1 HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC2, HDAC3 KDM4E 153/4885KMT2A 65/4885MAPT 1376/4885
US-10301323-B2 Histone deacetylase inhibitors HDAC1, HDAC2, HDAC3 KDM4E 153/4885KMT2A 65/4885MAPT 1376/4885
US-20200148704-A1 HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC2, HDAC3 KDM4E 153/4885KMT2A 65/4885MAPT 1376/4885
US-20100144732-A1 PYRIMIDINE KINASE INHIBITORS DTYMK, DCK, TYMP KDM4E 687/4885KMT2A 900/4885MAPT 4256/4885
US-10280182-B2 Histone deacetylase inhibitors HDAC1, HDAC2, HDAC3 KDM4E 153/4885KMT2A 65/4885MAPT 1376/4885
US-10981933-B2 Histone deacetylase inhibitors HDAC1, HDAC2, HDAC3 KDM4E 153/4885KMT2A 65/4885MAPT 1376/4885
US-20070219244-A1 Histone deacetylase inhibitors as therapeutics for neurological diseases HDAC5, HDAC1, HDAC6 KDM4E 133/4885KMT2A 40/4885MAPT 88/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.