Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | RAC1 | P63000 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91657 | 0.79 | SMN1; SMN2 (0.40) | MEN1TSHRKMT2ACYP1A2CYP3A4 | |
| SCHEMBL10104505 | 0.79 | PTPN5 (0.37) | MEN1TSHRKMT2ACYP1A2CYP3A4 | |
| SCHEMBL18897494 | 0.77 | NOS3 (0.39) | TSHRCYP1A2CYP2C19RAPGEF4ALDH1A1 | |
| SCHEMBL10104381 | 0.76 | NCF1 (0.38) | MEN1KMT2AALDH1A1 | |
| SCHEMBL9281840 | 0.75 | MEN1 (0.38) | MEN1TSHRKMT2AALOX15MAPK1 | |
| SCHEMBL20274229 | 0.75 | APP (0.49) | MEN1TSHRKMT2AALOX15MAPK1 | |
| SCHEMBL15761590 | 0.74 | SMN1; SMN2 (0.41) | TSHRALOX15HSD17B10CYP3A4RAPGEF4 | |
| SCHEMBL13550098 | 0.73 | RAPGEF4 (0.41) | MEN1TSHRKMT2AMAPK1HSD17B10 | |
| SCHEMBL83777 | 0.71 | SMN1; SMN2 (0.34) | MEN1TSHRKMT2ACYP1A2CYP3A4 | |
| SCHEMBL9229491 | 0.71 | TAS2R14 (0.53) | MEN1TSHRKMT2AALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271679-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-12-29 | — | — | WO | disclosed |