Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.75 |
| ▸ | NPC1 | O15118 | 5/20 | 0.75 |
| ▸ | RAB9A | P51151 | 5/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.75 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.75 |
| ▸ | RELA | Q04206 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | CISD2 | Q8N5K1 | 6/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.60 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289765 | 0.84 | ALDH1A1 (0.83) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL9400304 | 0.81 | RAB9A (1.00) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL23657451 | 0.79 | RAB9A (0.71) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL25106684 | 0.77 | CISD2 (1.00) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL25106697 | 0.77 | CISD2 (0.80) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL9732938 | 0.76 | MAPT (0.78) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL10933328 | 0.75 | POLB (0.51) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL25106671 | 0.75 | CISD2 (1.00) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL13236165 | 0.75 | ALDH1A1 (0.76) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL30300650 | 0.75 | CISD2 (1.00) | MAPTNPC1RAB9ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130171158-A1 | TREATMENT OF ABNORMALITIES OF GLUCOSE METABOLISM WITH AN ANTAGONIST OF INHIBITOR OF DIFFERENTIATION 1 | GARVAN INSTITUTE OF MEDICAL RESEARCH (AU) | 2013-07-04 | — | — | US | claimed |
| WO-2012000036-A1 | TREATMENT OF ABNORMALITIES OF GLUCOSE METABOLISM WITH AN ANTAGONIST OF INHIBITOR OF DIFFERENTIATION 1 | GARVAN INSTITUTE OF MEDICAL RESEARCH (AU) | 2012-01-05 | — | — | WO | claimed |
| US-20130171158-A1 | TREATMENT OF ABNORMALITIES OF GLUCOSE METABOLISM WITH AN ANTAGONIST OF INHIBITOR OF DIFFERENTIATION 1 | GARVAN INSTITUTE OF MEDICAL RESEARCH (AU) | 2013-07-04 | — | — | US | disclosed |
| US-8138356-B2 | Chemical inhibitors of inhibitors of differentiation | Angiogeney, Inc. (US) | 2012-03-20 | — | — | US | disclosed |
| WO-2012000036-A1 | TREATMENT OF ABNORMALITIES OF GLUCOSE METABOLISM WITH AN ANTAGONIST OF INHIBITOR OF DIFFERENTIATION 1 | GARVAN INSTITUTE OF MEDICAL RESEARCH (AU) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130171158-A1 | TREATMENT OF ABNORMALITIES OF GLUCOSE METABOLISM WITH AN ANTAGONIST OF INHIBITOR OF DIFFERENTIATION 1 | FBP1, G6PC1, G6PD | MAPT 4187/4885NPC1 1637/4885RAB9A 4386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.