SCHEMBL24909776

SCHEMBL24909776

CC#Cc1cncc(-c2cc(C#N)cc(C(F)(F)F)c2O)c1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.40
METAP2 P50579 1/20 0.40
BACE1 P56817 5/20 0.37
KCNH2 Q12809 2/20 0.37
PTGES O14684 1/20 0.36
USP7 Q93009 2/20 0.34
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33
WDR5 P61964 1/20 0.32
ABL1 P00519 2/20 0.32
XDH P47989 2/20 0.31
SLC22A12 Q96S37 2/20 0.31
TTR P02766 1/20 0.30
ALB P02768 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24909792 0.82 CYP11B2 (0.45) CYP1A2METAP2CYP11B1CYP11B2XDH
SCHEMBL24909865 0.81 TTR (0.46) CYP1A2METAP2BACE1KCNH2USP7
SCHEMBL24909890 0.81 CYP11B1 (0.47) CYP1A2METAP2CYP11B1CYP11B2SLC22A12
SCHEMBL24909774 0.74 KIF11 (0.40) XDHSLC22A12TTRALB
SCHEMBL24909746 0.74 GYS1 (0.35) CYP11B2XDHSLC22A12TTRALB
SCHEMBL24909893 0.73 KIF11 (0.40) CYP11B1CYP11B2XDHSLC22A12
SCHEMBL24909762 0.73 RXRA (0.46) CYP1A2METAP2XDHSLC22A12TTR
SCHEMBL24909915 0.73 KIF11 (0.41) XDHSLC22A12TTRALB
SCHEMBL24909935 0.73 KIF11 (0.36) CYP11B2XDHSLC22A12
SCHEMBL24909923 0.73 KIF11 (0.36) XDHSLC22A12TTRALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230024283-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230024283-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 CYP1A2 69/4885METAP2 1494/4885BACE1 3310/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.