Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4510130 | 0.82 | MAPT (0.51) | KDM4EMAPTTDP1POLBSMN1; SMN2 | |
| SCHEMBL17786273 | 0.81 | HDAC4 (0.50) | KDM4EHSD17B10MAPTTDP1HDAC4 | |
| SCHEMBL660605 | 0.79 | MAPT (0.55) | MAPTTDP1PDE4DSMN1; SMN2LMNA | |
| SCHEMBL2464591 | 0.79 | IKBKB (0.48) | KDM4EHSD17B10L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28473659 | 0.77 | MAPT (0.53) | MAPTTDP1PDE4DSMN1; SMN2LMNA | |
| SCHEMBL27621848 | 0.76 | HDAC4 (0.57) | KDM4EMAPTTDP1HDAC4HDAC2 | |
| SCHEMBL9765827 | 0.73 | MAPT (0.49) | KDM4EHSD17B10MAPTTDP1POLB | |
| SCHEMBL1496439 | 0.73 | NNMT (0.46) | KDM4EMAPTTDP1POLBSMN1; SMN2 | |
| SCHEMBL3421092 | 0.71 | MAPT (0.50) | KDM4EMAPTTDP1POLBPDE4D | |
| SCHEMBL10407306 | 0.71 | TDP1 (0.50) | KDM4EMAPTTDP1POLBPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012956-B2 | Tropane compounds | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | claimed |
| US-20090163471-A1 | Tropane compounds | EXELIXIS, INC. | 2009-06-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163471-A1 | Tropane compounds | ADRA1B, ADRA2B, ADRB2 | KDM4E 4402/4885HSD17B10 1069/4885MAPT 586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.