Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | MAP2 | P11137 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | GRK6 | P43250 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4117320 | 0.81 | MYC (0.54) | IKBKBPARP1MAP2CDC7KEAP1 | |
| SCHEMBL5582517 | 0.80 | PARP1 (0.52) | IKBKBPARP1MAP2CDC7KEAP1 | |
| SCHEMBL2491692 | 0.79 | KDM4E (0.43) | ALDH1A1HSD17B10L3MBTL1KDM4E | |
| SCHEMBL3675429 | 0.79 | EGFR (0.47) | IKBKBPARP1MAP2CDC7ALDH1A1 | |
| SCHEMBL527995 | 0.78 | PARP1 (0.56) | IKBKBPARP1CDC7KEAP1NFE2L2 | |
| SCHEMBL5517143 | 0.78 | PARP1 (0.50) | IKBKBPARP1MAP2CDC7KEAP1 | |
| SCHEMBL165834 | 0.76 | HTT (0.49) | PARP1ALDH1A1KDM4EIRAK4CTSD | |
| SCHEMBL41435 | 0.75 | KEAP1 (0.64) | PARP1KEAP1NFE2L2GRK6ALDH1A1 | |
| SCHEMBL15517040 | 0.75 | GPR35 (0.57) | ALDH1A1HPGDGAAHSD17B10APP | |
| SCHEMBL264288 | 0.74 | IRAK4 (0.63) | ALDH1A1HPGDL3MBTL1IRAK4CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012956-B2 | Tropane compounds | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | claimed |
| US-20090163471-A1 | Tropane compounds | EXELIXIS, INC. | 2009-06-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163471-A1 | Tropane compounds | ADRA1B, ADRA2B, ADRB2 | IKBKB 3815/4885PARP1 3161/4885MAP2 1148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.