Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1041158 | 0.84 | ALDH1A1 (0.41) | MAPK1TP53ALDH1A1KDM4EHPGD | |
| SCHEMBL2752323 | 0.82 | AHR (0.43) | TP53NOTUMALDH1A1KDM4EHPGD | |
| SCHEMBL5331004 | 0.82 | ALDH1A1 (0.41) | NR1H2NR1H3ALDH1A1KMT2ARAB9A | |
| SCHEMBL2753284 | 0.80 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2RAB9AHSD11B1 | |
| SCHEMBL2749854 | 0.76 | USP2 (0.46) | USP2NOTUMALDH1A1MEN1KMT2A | |
| SCHEMBL2751909 | 0.74 | HSD11B1 (0.50) | USP2ALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL2754046 | 0.74 | HSD11B1 (0.39) | MAPK1TP53ALDH1A1LMNAPDE4D | |
| SCHEMBL2751797 | 0.74 | METAP2 (0.34) | — | |
| SCHEMBL2752630 | 0.73 | HSD11B1 (0.35) | ALDH1A1LMNAHSD11B1 | |
| SCHEMBL2751965 | 0.71 | NOTUM (0.39) | NOTUMEGLN2ARHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070088063-A1 | Gamma-secretase inhibitors | CASTRO PINEIRO JOSE L | 2007-04-19 | — | — | US | claimed |
| US-7183303-B2 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2007-02-27 | — | — | US | claimed |
| US-20050143369-A1 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LTD. (GB) | 2005-06-30 | — | — | US | claimed |
| US-8222418-B2 | Piperidines and related compounds for the treatment of dementia | Merck Sharp + Dohme Corp. (US) | 2012-07-17 | — | — | US | disclosed |
| EP-2001848-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR THE TREATMENT OF DEMENTIA | MERCK SHARP & DOHME (GB) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010069069-A1 | CATHEPSIN B INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2010-06-24 | — | — | WO | disclosed |
| US-7728022-B2 | (3-phenyl-1-{1-[4-(trifluoromethyl)phenyl]butyl}-4,5,6,7-tetrahydro-1H-indol-7-yl)acetic acid, used for treating diseases associated with the deposition of beta -amyloid peptide in the brain | MERCK SHARP & DOHME LTD. (GB) | 2010-06-01 | — | — | US | disclosed |
| EP-1656141-B1 | TREATMENT FOR ALZHEIMER S DISEASE AND RELATED CONDITIONS | MERCK SHARP & DOHME (GB) | 2010-04-14 | — | — | EP | disclosed |
| US-20100048717-A1 | CATHEPSIN B INHIBITORS | MERCK FROSST CANADA LTD, Merk & Co., Inc. (US) | 2010-02-25 | — | — | US | disclosed |
| US-20100048555-A1 | IMIDAZOTHIAZOLE DERIVATIVES AS MARK INHIBITORS | MERCK SHARP & DOHME LIMITED (GB) | 2010-02-25 | — | — | US | disclosed |
| EP-1805141-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2010-01-20 | — | — | EP | disclosed |
| EP-1773315-B1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2008-01-16 | — | — | EP | disclosed |
| US-20070232678-A1 | (4, 5, 6, 7-Tetrahydro-1-H-Indol-7-Yl) Acetic Acid Derivatives for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LTD. (GB) | 2007-10-04 | — | — | US | disclosed |
| US-20070142453-A1 | 1-Alkyl-3-thio-substituted indole-2-alkynoic acids useful for the treatment of alzheimer's disease and related conditions | BEHER DIRK | 2007-06-21 | — | — | US | disclosed |
| US-20070088063-A1 | Gamma-secretase inhibitors | CASTRO PINEIRO JOSE L | 2007-04-19 | — | — | US | disclosed |
| EP-1773315-A1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | Merck Sharp & Dohme Limited (GB) | 2007-04-18 | — | — | EP | disclosed |
| US-7183303-B2 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2007-02-27 | — | — | US | disclosed |
| US-20060121034-A1 | Treatment for alzheimer's disease and related conditions | MERCK SHARP & DOHME LTD. (GB) | 2006-06-08 | — | — | US | disclosed |
| WO-2006008558-A1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER’S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-01-26 | — | — | WO | disclosed |
| US-20050143369-A1 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LTD. (GB) | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232678-A1 | (4, 5, 6, 7-Tetrahydro-1-H-Indol-7-Yl) Acetic Acid Derivatives for Treatment of Alzheimer's Disease | APP, BACE1, CHAT | MAPK1 1566/4885USP2 2700/4885TP53 1962/4885 |
| US-20070142453-A1 | 1-Alkyl-3-thio-substituted indole-2-alkynoic acids useful for the treatment of alzheimer's disease and related conditions | BACE1, PSEN1, APP | MAPK1 2019/4885USP2 2352/4885TP53 2711/4885 |
| US-20060121034-A1 | Treatment for alzheimer's disease and related conditions | IAPP, APP, GHSR | MAPK1 1354/4885USP2 1980/4885TP53 1616/4885 |
| US-20100048717-A1 | CATHEPSIN B INHIBITORS | CTSB, CTSF, CTSS | MAPK1 3214/4885USP2 1307/4885TP53 1045/4885 |
| US-20070088063-A1 | Gamma-secretase inhibitors | BACE1, BACE2, PSEN1 | MAPK1 2569/4885USP2 1506/4885TP53 1926/4885 |
| US-20100048555-A1 | IMIDAZOTHIAZOLE DERIVATIVES AS MARK INHIBITORS | MAPT, MARK1, MARK4 | MAPK1 257/4885USP2 2621/4885TP53 490/4885 |
| US-20050143369-A1 | Gamma-secretase inhibitors | BACE1, BACE2, PSEN1 | MAPK1 2569/4885USP2 1506/4885TP53 1926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.