Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 4/20 | 0.36 |
| ▸ | NOS3 | P29474 | 3/20 | 0.36 |
| ▸ | NOS1 | P29475 | 3/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ARG1 | P05089 | 3/20 | 0.31 |
| ▸ | ARG2 | P78540 | 3/20 | 0.31 |
| ▸ | Q9HBH1 | 1/20 | 0.31 | |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL30958396 | 0.80 | ALDH1A1 (0.40) | NOS2NOS3NOS1GRIK1GRIK2 | |
| SCHEMBL14311843 | 0.78 | NOS2 (0.40) | NOS2NOS3NOS1GSRDPP4 | |
| SCHEMBL6670962 | 0.75 | GABRP (0.41) | NOS2NOS3NOS1SLC1A2SLC1A1 | |
| SCHEMBL3893609 | 0.75 | NOS3 (0.32) | NOS2NOS3NOS1 | |
| SCHEMBL3893611 | 0.75 | NOS3 (0.32) | NOS2NOS3NOS1 | |
| SCHEMBL6245968 | 0.72 | NOS3 (0.33) | NOS2NOS3NOS1 | |
| SCHEMBL1852682 | 0.72 | NOS3 (0.33) | NOS2NOS3NOS1 | |
| SCHEMBL6665323 | 0.72 | ALDH1A1 (0.35) | NOS2NOS3NOS1GRIK1GRIK2 | |
| SCHEMBL838138 | 0.72 | CHRM2 (0.38) | GSRCYP1A2TSHR | |
| SCHEMBL2280440 | 0.72 | GSR (0.57) | NOS2NOS3NOS1GSRDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030499-B2 | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-10-04 | — | — | US | disclosed |
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | AVPR1B, AVPR1A, AVPR2 | NOS2 635/4885NOS3 1863/4885NOS1 937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.