SCHEMBL249533

SCHEMBL249533

NC(=NO)Nc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIN2D O15399 1/20 0.63
GRIN3B O60391 1/20 0.63
LMNA P02545 1/20 0.63
CYP2D6 P10635 1/20 0.63
SLC6A2 P23975 1/20 0.63
KMT2A Q03164 1/20 0.63
GRIN1 Q05586 1/20 0.63
GRIN2A Q12879 1/20 0.63
GRIN2B Q13224 1/20 0.63
GRIN2C Q14957 1/20 0.63
GRIN3A Q8TCU5 1/20 0.63
SIGMAR1 Q99720 1/20 0.63
TDP1 Q9NUW8 1/20 0.63
KDM1A O60341 1/20 0.62
ALDH1A1 P00352 3/20 0.54
TP53 P04637 2/20 0.54
TSHR P16473 2/20 0.54
TAS2R38 P59533 2/20 0.54
HSD17B10 Q99714 2/20 0.54
TYR P14679 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14739674 1.00 GRIN2D (0.63) GRIN2DGRIN3BLMNACYP2D6SLC6A2
SCHEMBL14755313 1.00 GRIN2D (0.63) GRIN2DGRIN3BLMNACYP2D6SLC6A2
SCHEMBL11655504 0.81 GRIN2D (0.63) GRIN2DGRIN3BLMNACYP2D6SLC6A2
SCHEMBL10625419 0.81 GRIN2D (0.63) GRIN2DGRIN3BLMNACYP2D6SLC6A2
SCHEMBL5580193 0.79 PEPD (0.56) GRIN2DGRIN3BLMNACYP2D6SLC6A2
SCHEMBL1743266 0.79 HTR3E (0.61) GRIN2DGRIN3BLMNACYP2D6SLC6A2
SCHEMBL14952315 0.79 HTR3E (0.61) GRIN2DGRIN3BLMNACYP2D6SLC6A2
SCHEMBL13358496 0.79 HTR3E (0.61) GRIN2DGRIN3BLMNACYP2D6SLC6A2
SCHEMBL2273066 0.77 NPC1 (0.57) LMNACYP2D6SLC6A2KMT2ASIGMAR1
SCHEMBL28515024 0.77 GRIN2D (0.66) GRIN2DGRIN3BKMT2AGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008157537-A2 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC (US) 2008-12-24 WO claimed
US-20260116886-A1 DEUTERATED sGC STIMULATORS TISENTO THERAPEUTICS INC (US) 2026-04-30 US disclosed
US-20260000653-A1 TREATMENT OF CNS DISEASES WITH sGC STIMULATORS TISENTO THERAPEUTICS INC (US) 2026-01-01 US disclosed
US-20250326761-A1 sGC STIMULATORS TISENTO THERAPEUTICS INC (US) 2025-10-23 US disclosed
US-12435080-B2 sGC stimulators TISENTO THERAPEUTICS INC. (US) 2025-10-07 US disclosed
US-20250243177-A1 sGC STIMULATORS CYCLERION THERAPEUTICS, INC. 2025-07-31 US disclosed
US-20250243205-A1 sGC STIMULATORS TISENTO THERAPEUTICS INC (US) 2025-07-31 US disclosed
US-20250243228-A1 PHOSPHORUS PRODRUGS OF PYRAZOLO-SUBSTITUTED PYRIMIDINE sGC STIMULATORS CYCLERION THERAPEUTICS, INC. 2025-07-31 US disclosed
US-20250129060-A1 SOLID FORMS OF AN SGC STIMULATOR CYCLERION THERAPEUTICS INC (US) 2025-04-24 US disclosed
US-20250115611-A1 CRYSTALLINE FORMS OF 8-(2-FLUOROBENZYL)-6-(3-(TRIFLUOROMETHYL)-1H-1,2,4-TRIAZOL-5-YL)IMIDAZO[1,2-a]PYRAZINE AS sGC STIMULATORS TISENTO THERAPEUTICS INC. 2025-04-10 US disclosed
US-20110160225-A1 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC. (US) 2011-06-30 US disclosed
US-20100215779-A1 Compositions and Methods for Treating Disorders Associated with Salt or Fluid Retention IRONWOOD PHARMACEUTICALS, INC. 2010-08-26 US disclosed
US-20100144864-A1 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC. (US) 2010-06-10 US disclosed
EP-2152266-A1 COMPOSITIONS AND METHODS FOR TREATING DISORDERS ASSOCIATED WITH SALT OR FLUID RETENTION Ironwood Pharmaceuticals, Inc. (US) 2010-02-17 EP disclosed
US-20090054450-A1 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC. (US) 2009-02-26 US disclosed
WO-2008157537-A2 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC (US) 2008-12-24 WO disclosed
WO-2008137318-A1 COMPOSITIONS AND METHODS FOR TREATING DISORDERS ASSOCIATED WITH SALT OR FLUID RETENTION IRONWOOD PHARMACEUTICALS, INC. (US) 2008-11-13 WO disclosed
CN-1441637-A Compositions for repelling crawling insects BAYER AG (DE) 2003-09-10 CN disclosed
EP-0261710-B1 PHENYLUREA HERBICIDES SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1990-05-23 EP disclosed
EP-0261710-A1 Phenylurea herbicides SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1988-03-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100144864-A1 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS GUCY1A2, GUCY1B2, GUCY1B1 GRIN2D 3516/4885GRIN3B 1778/4885LMNA 1692/4885
US-20250326761-A1 sGC STIMULATORS GUCY1A2, PRKG1, GMPS GRIN2D 3760/4885GRIN3B 1338/4885LMNA 3091/4885
US-20110160225-A1 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS LIPC, PNLIP, LIPA GRIN2D 4058/4885GRIN3B 3620/4885LMNA 531/4885
US-20250243228-A1 PHOSPHORUS PRODRUGS OF PYRAZOLO-SUBSTITUTED PYRIMIDINE sGC STIMULATORS P2RY1, P2RY11, GMPS GRIN2D 2031/4885GRIN3B 946/4885LMNA 4090/4885
US-12435080-B2 sGC stimulators GUCY1A2, PRKG1, PDE2A GRIN2D 3546/4885GRIN3B 1033/4885LMNA 3153/4885
US-20250129060-A1 SOLID FORMS OF AN SGC STIMULATOR GUCY1A2, PRKG1, GUCY1A1 GRIN2D 2846/4885GRIN3B 779/4885LMNA 1783/4885
US-20260116886-A1 DEUTERATED sGC STIMULATORS PDE2A, PRKG1, GUCY1A2 GRIN2D 2823/4885GRIN3B 3299/4885LMNA 2703/4885
US-20090054450-A1 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS LIPC, PNLIP, LIPA GRIN2D 4058/4885GRIN3B 3620/4885LMNA 531/4885
US-20260000653-A1 TREATMENT OF CNS DISEASES WITH sGC STIMULATORS PDE9A, PDE2A, GUCY1A2 GRIN2D 498/4885GRIN3B 442/4885LMNA 2031/4885
US-20250243177-A1 sGC STIMULATORS GUCY1A1, PTGIS, GUCY1B1 GRIN2D 4206/4885GRIN3B 1559/4885LMNA 3689/4885
US-20250115611-A1 CRYSTALLINE FORMS OF 8-(2-FLUOROBENZYL)-6-(3-(TRIFLUOROMETHYL)-1H-1,2,4-TRIAZOL-5-YL)IMIDAZO[1,2-a]PYRAZINE AS sGC STIMULATORS GUCY1A2, GUCY1B2, GUCY1A1 GRIN2D 2440/4885GRIN3B 1519/4885LMNA 1840/4885
US-20100215779-A1 Compositions and Methods for Treating Disorders Associated with Salt or Fluid Retention SLC10A2, SLC10A1, SLC26A3 GRIN2D 3201/4885GRIN3B 2600/4885LMNA 1333/4885
US-20250243205-A1 sGC STIMULATORS GMPS, GUCY1A2, PDE2A GRIN2D 4176/4885GRIN3B 1888/4885LMNA 3247/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.