Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24963385 | 0.75 | LMNA (0.43) | LMNAGAASMN1; SMN2POLB | |
| SCHEMBL24964991 | 0.74 | CES2 (0.48) | LMNAGAAPOLB | |
| SCHEMBL24963420 | 0.72 | LMNA (0.41) | PROKR1LMNAPOLB | |
| SCHEMBL24964824 | 0.71 | LMNA (0.54) | LMNAPLAUSMN1; SMN2POLBHTT | |
| SCHEMBL5958342 | 0.69 | — | — | |
| SCHEMBL24963538 | 0.69 | CCR9 (0.38) | PROKR1MAP4K4LMNAPOLB | |
| SCHEMBL24962584 | 0.69 | LMNA (0.50) | LMNAPOLB | |
| SCHEMBL24964826 | 0.69 | LMNA (0.37) | MAP4K4LMNAKCNH2POLB | |
| Hydrochloric Acid SCHEMBL22578833 | 0.68 | PLAU (0.43) | LMNAMKNK1MKNK2PLAUSMN1; SMN2 | |
| SCHEMBL24964808 | 0.67 | CNR1 (0.37) | PROKR1MAP4K4LMNAPLAUPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023004280-A1 | SELECTIVE PYRAZOLE LRRK2 INHIBITORS AND METHODS FOR USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2023-01-26 | — | — | WO | disclosed |