Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24963385 | 0.80 | LMNA (0.43) | LMNAPOLBKMT2AMEN1NT5E | |
| SCHEMBL24963420 | 0.71 | LMNA (0.41) | LMNAPOLBNPC1RAB9A | |
| SCHEMBL24963538 | 0.71 | CCR9 (0.38) | LMNAIDO1POLBMAP4K4 | |
| SCHEMBL11001665 | 0.70 | TDP1 (0.50) | SIRT3TDP1KMT2AMEN1 | |
| SCHEMBL24964824 | 0.70 | LMNA (0.54) | LMNATDP1IDO1POLBNPC1 | |
| SCHEMBL24964991 | 0.70 | CES2 (0.48) | LMNAPOLBKMT2A | |
| SCHEMBL24963419 | 0.69 | LMNA (0.36) | LMNATDP1POLBNPC1RAB9A | |
| SCHEMBL24962589 | 0.69 | PROKR1 (0.39) | LMNAPOLBMAP4K4KCNH2 | |
| SCHEMBL24962584 | 0.68 | LMNA (0.50) | LMNAIDO1POLB | |
| SCHEMBL24964808 | 0.66 | CNR1 (0.37) | LMNAPOLBMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023004280-A1 | SELECTIVE PYRAZOLE LRRK2 INHIBITORS AND METHODS FOR USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2023-01-26 | — | — | WO | disclosed |